Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?

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dc.authorscopusid42661653300
dc.authorscopusid56406426000
dc.authorscopusid23968920100
dc.authorscopusid56406245700
dc.authorscopusid56406174400
dc.authorscopusid55481926000
dc.authorscopusid37058172000
dc.contributor.authorGüzel, Eda Çelik
dc.contributor.authorBakkal, Esra
dc.contributor.authorGüzel, Savaş
dc.contributor.authorEroğlu, Hasan Emre
dc.contributor.authorAcar, Ayşe
dc.contributor.authorKüçükyalçın, Volkan
dc.contributor.authorTopçu, Birol
dc.date.accessioned2022-05-11T14:10:11Z
dc.date.available2022-05-11T14:10:11Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractObjective: Depression is a common condition in obese women that can result in severe impairment of their physical and social functioning. A deficiency of brain-derived neurotrophic factor (BDNF) is involved in the mechanism of depression. The aim of this study is to investigate whether BDNF levels differ between obese female patients and healthy controls and whether BDNF levels alter with affective states in depressive obese women. Methods: The study group included 40 obese, 40 preobese, and 40 normal weight women. BDNF levels were measured with an enzyme-linked immunosorbent assay in patient and control groups. For identifying the depression and anxiety status, Beck Depression/Anxiety Inventories were used; and for the evaluation of cognitive functions, the mini-mental state examination was used. Results: BDNF levels were significantly lower in obese patients compared to the control group (P. 0.01). BDNF levels were significantly lower in obese patients with depression compared to the obese patients without depression (P<0.05). The Beck Depression Inventory showed a negative correlation with BDNF (r=-0.044; P<0.01) and a positive correlation with the Beck Anxiety Inventory (r= 0.643; P<0.001), vitamin B12 levels (r= 0.023; P<0.001), and insulin levels (r= 0.257; P<0.05) in obese patients. When receiver operating characteristic curve analysis was used to analyze the suitability of BDNF to identify depression in obese women, the area under the curve for BDNF, 0.756, was found to be significant (P=0.025). BDNF levels lower than 70.2 pg/mL were associated with a higher prevalence of depressive symptoms. Conclusion: The results of our study suggest that the decrease in BDNF levels can be used as a marker for depression diagnosis in obese patients.
dc.identifier.doi10.2147/NDT.S72087
dc.identifier.endpage2086
dc.identifier.issn1178-2021
dc.identifier.pmid25395856
dc.identifier.scopus2-s2.0-84908692925
dc.identifier.scopusqualityQ2
dc.identifier.startpage2079
dc.identifier.urihttps://doi.org/10.2147/NDT.S72087
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5316
dc.identifier.volume10
dc.identifier.wosWOS:000344928000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüzel, Eda Çelik
dc.institutionauthorBakkal, Esra
dc.institutionauthorGüzel, Savaş
dc.institutionauthorEroğlu, Hasan Emre
dc.institutionauthorAcar, Ayşe
dc.institutionauthorKüçükyalçın, Volkan
dc.institutionauthorTopçu, Birol
dc.language.isoen
dc.publisherDove Medical Press Ltd
dc.relation.ispartofNeuropsychiatric Disease and Treatment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectobesity
dc.subjectbrain-derived neurotrophic factor
dc.subjectcomorbidity
dc.subjectNatriuretic Peptide Levels
dc.subjectHeart-Failure
dc.subjectPsychiatric-Disorders
dc.subjectMajor Depression
dc.subjectAnxiety Symptoms
dc.subjectInflammation
dc.subjectSystem
dc.subjectImpact
dc.subjectBnp
dc.subjectDyslipidemia
dc.titleCan low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?
dc.typeArticle

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