Antioxidant and anti-apoptotic effects of onion (Allium cepa) extract on doxorubicin-induced cardiotoxicity in rats

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dc.authorid0000-0001-7121-6077
dc.authorscopusid6505680586
dc.authorscopusid24436194200
dc.authorscopusid26434076100
dc.authorscopusid37058172000
dc.authorscopusid7006356462
dc.authorscopusid36023238400
dc.authorscopusid55881642200
dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.authorwosidGedikbasi, Asuman/AAE-3613-2020
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorAktaş, Cevat
dc.contributor.authorUygur, Ramazan
dc.contributor.authorTopçu, Birol
dc.contributor.authorKanter, Mehmet
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorGedikbaşı, Asuman
dc.date.accessioned2022-05-11T14:09:56Z
dc.date.available2022-05-11T14:09:56Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThe aim of this study was to investigate the antioxidant and anti-apoptotic effects of onion (Allium cepa) extracts (ACE) on doxorubicin (DOX)-induced cardiotoxicity. The rats in the ACE-pretreated group were given a daily dose of 1 ml ACE for 14 days. To induce cardiotoxicity, DOX (30 mg kg-1 body weight) was injected intraperitoneally by a single dose and the rats were sacrificed after 48 h. To date, no such studies have been performed on the cardioprotective and anti-apoptotic potential of ACE on DOX-induced cardiotoxicity. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end-labeling in cardiomyocytes of the DOX-treated group with ACE therapy. The DOX-treated with ACE groups showed a significant decrease in malondialdehyde levels, and increased activities of superoxide dismutase, glutathione and glutathione peroxidase in comparison with the DOX-treated group. Creatine kinase, creatine kinase MB, lactate dehydrogenase activities and cardiac troponin I levels were significantly decreased in the DOX + ACE group in comparison with the DOX group. These biochemical and histological disturbances were effectively attenuated on pretreatment with ACE. The present study showed that ACE may be a suitable cardioprotector against toxic effects of DOX. Copyright (C) 2011 John Wiley & Sons, Ltd.
dc.identifier.doi10.1002/jat.1738
dc.identifier.endpage208
dc.identifier.issn0260-437X
dc.identifier.issn1099-1263
dc.identifier.issue3en_US
dc.identifier.pmid21996788
dc.identifier.scopus2-s2.0-84873059182
dc.identifier.scopusqualityQ2
dc.identifier.startpage202
dc.identifier.urihttps://doi.org/10.1002/jat.1738
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5206
dc.identifier.volume33
dc.identifier.wosWOS:000314070200006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorAktaş, Cevat
dc.institutionauthorUygur, Ramazan
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Applied Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectdoxorubicin
dc.subjectAllium cepa
dc.subjectcardiotoxicity
dc.subjectTUNEL
dc.subjectantioxidants
dc.subjectrat
dc.subjectCytochrome-C Release
dc.subjectAdriamycin
dc.subjectProtection
dc.subjectHeart
dc.subjectInhibition
dc.subjectEfficiency
dc.subjectDamage
dc.titleAntioxidant and anti-apoptotic effects of onion (Allium cepa) extract on doxorubicin-induced cardiotoxicity in rats
dc.typeArticle

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