Osteopontin expression in the intestine of chukar partridge (Alectoris chukar, Gray, 1830)

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dc.authorwosidErdogan, Serkan/F-5923-2011
dc.contributor.authorAkbalık, Mehmet Erdem
dc.contributor.authorSağsöz, Hakan
dc.contributor.authorErdoğan, Serkan
dc.date.accessioned2022-05-11T14:42:23Z
dc.date.available2022-05-11T14:42:23Z
dc.date.issued2015
dc.departmentFakülteler, Veteriner Fakültesi, Temel Bilimler Bölümü, Anatomi Ana Bilim Dalı
dc.description.abstractThe intestinal mucosa is under continuous attack of microorganisms and is defended by the joint action of epithelial cells and specialized immune cells. Osteopontin (OPN), a member of the Small Integrin-Binding Ligand, N-linked Glycoprotein (SIBLING) family, is an adhesive phosphorylated glyco-protein that is synthesized by a variety of nonimmune and immune cells that is involved in interactions with cells mediating signaling. OPN is especially required for the maintenance of the epithelial barrier. To gain a better understanding of the biology of OPN, in the avian intestinal tract, we examined subcellular localization of OPN in the small and large intestine using immunohistochemistry. Immunostaining for OPN was prominently and significantly detected in the epithelial cells of the small and large intestine. However, intestinal stromal cells of the small intestine and the smooth muscle cells in the wall of the large intestine did not exhibit OPN immunoreactivity. Our results show that the differences between the localizations of OPN in the chukar partridge's small and large intestine may be associated with functional differences of intestine parts. Therefore, the expression of OPN in the chukar partridge intestine may play a crucial role in barrier function, host defence, and/or secretion.
dc.identifier.doi10.1163/15707563-00002477
dc.identifier.endpage298
dc.identifier.issn1570-7555
dc.identifier.issn1570-7563
dc.identifier.issue45385en_US
dc.identifier.startpage287
dc.identifier.urihttps://doi.org/10.1163/15707563-00002477
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9359
dc.identifier.volume65
dc.identifier.wosWOS:000367519100008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.institutionauthorErdoğan, Serkan
dc.language.isoen
dc.publisherBrill Academic Publishers
dc.relation.ispartofAnimal Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBarrier function
dc.subjectimmunohistochemistry
dc.subjectintestine
dc.subjectosteopontin
dc.subjectpartridge
dc.subjectEpithelial-Cells
dc.subjectHuman Tissues
dc.subjectBone
dc.subjectSurvival
dc.subjectProgression
dc.subjectMetastasis
dc.subjectReceptors
dc.subjectCancer
dc.subjectEta-1
dc.subjectIleum
dc.titleOsteopontin expression in the intestine of chukar partridge (Alectoris chukar, Gray, 1830)
dc.typeArticle

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