The importance of p16 and CD117 expression in melanocytic lesions

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dc.contributor.authorArslan, Ayşegül İsal
dc.contributor.authorKarabağ, Sevil
dc.date.accessioned2023-05-06T17:22:12Z
dc.date.available2023-05-06T17:22:12Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractAim: The present study aims to determine the p16 and CD117 expression profiles of melanocytic lesions to investigate immune profiles that may facilitate differential diagnosis of melanoma from benign or potential precursor melanocytic lesions.Materials and Methods: Immunohistochemistry for p16 and CD117 was applied in a total of 81 cases with melanocytic lesions.Results: A significant loss of p16 expression was found in melanoma cases compared to benign and precursor melanocytic lesions (p<0.05). Moreover, a significant loss of p16 expression was also noted in cases of dysplastic nevus compared to those with intradermal nevus (p<0.01). While no CD117 expression was observed in intradermal nevi, high-level expression was seen in cases with Spitz nevus, blue nevus, invasive melanoma and dysplastic nevus (p<0.01).Conclusion: We believe using p16 and CD117 together may provide an important marker combination to aid in distinguishing melanoma from benign lesions and benign lesions from potential precursor melanocytic lesions.
dc.identifier.doi10.30569/adiyamansaglik.890978
dc.identifier.endpage119
dc.identifier.issn2458-9179
dc.identifier.issue2en_US
dc.identifier.startpage113
dc.identifier.trdizinid1131511
dc.identifier.urihttps://doi.org/10.30569/adiyamansaglik.890978
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1131511
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12106
dc.identifier.volume7
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorArslan, Ayşegül İsal
dc.institutionauthorKarabağ, Sevil
dc.language.isoen
dc.relation.ispartofAdıyaman Üniversitesi Sağlık Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMelanocytic tumors
dc.subjectImmunohistochemistry
dc.subjectP16
dc.subjectCD117
dc.titleThe importance of p16 and CD117 expression in melanocytic lesions
dc.typeArticle

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