Protective Effect of Nigella Sativa in an Animal Model of Colon Anastomosis With Ischemia/Reperfusion Injury

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dc.authorid0000-0003-4672-7662
dc.authorid0000-0003-2006-9198
dc.authorid0000-0001-6758-7289
dc.authorscopusid55624501100
dc.authorscopusid8855691800
dc.authorscopusid35791793300
dc.authorscopusid35410250800
dc.authorscopusid54584164400
dc.authorscopusid57210185544
dc.authorscopusid17433815200
dc.authorwosidBilir, Bülent/AAK-5656-2021
dc.authorwosidCOSKUNKAN, UFUK/AAE-8852-2021
dc.authorwosidAZİRET, MEHMET/I-5483-2014
dc.authorwosidSözen, Selim/ABA-6337-2020
dc.contributor.authorBali, İlhan
dc.contributor.authorPolat, Fatin Rüştü
dc.contributor.authorAziret, Mehmet
dc.contributor.authorSözen, Selim
dc.contributor.authorOruc, Cem
dc.contributor.authorCoskunkan, Ufuk
dc.contributor.authorKoç, Ahmet
dc.contributor.authorBilir, Bülent
dc.contributor.authorEmir, Seyfi
dc.date.accessioned2022-05-11T14:10:12Z
dc.date.available2022-05-11T14:10:12Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractObjective: Anastomotic leaks are one of the chief complications after gastrointestinal surgery. The aim of this study was to evaluate whether Nigella sativa administration protects against ischemia/reperfusion injury on healing of colonic anastomosis in rats. Method: Thirty male Wistar albino rats, weighing between 200 and 240 g, were used in the study. They were randomly divided into three groups (n = 10 for each group): Anastomosis (group 1), anastomosis and ischemia/reperfusion injury (group 2), and treatment group of anastomosis, ischemia/reperfusion injury, and Nigella sativa (group 3). After 7 days, serum, plasma, and colonic tissue were obtained and then all rats were sacrificed. Tissue and serum level of total oxidant status, total antioxidant status, total thiol levels, hydroxyproline, interleukin-6, and TNF-alpha were determined and specimens were histopathologically evaluated. Results: In the Nigella sativa treated rats, serum hydroxyproline levels were significantly higher, while tissue levels were significantly lower than those seen in group 1 and group 2 (P = 0.007, P = 0.01, respectively). In the Nigella sativa group, the serum levels of TNF-alpha were significantly lower than those seen in group 1 and 2 (P = 0.001). Also, in group 3, the tissue IL-6 level was significantly higher than that seen in group 1 and group 2 (P = 0.009). The histopathologic analysis showed less edema and inflammatory cell infiltration in the Nigella sativa treated group, as well as a statistically significant difference according to the Chiu classification (P < 0.05). Conclusion: The results of this study indicate that Nigella sativa has a protective and therapeutic effect against ischemia/reperfusion injury on the healing of colonic anastomosis in rats.
dc.identifier.doi10.9738/INTSURG-D-15-00301.1
dc.identifier.endpage148
dc.identifier.issn0020-8868
dc.identifier.issue45385en_US
dc.identifier.scopus2-s2.0-85069832347
dc.identifier.scopusqualityQ4
dc.identifier.startpage139
dc.identifier.urihttps://doi.org/10.9738/INTSURG-D-15-00301.1
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5321
dc.identifier.volume103
dc.identifier.wosWOS:000474607300004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBali, İlhan
dc.institutionauthorPolat, Fatin Rüştü
dc.institutionauthorSözen, Selim
dc.institutionauthorCoskunkan, Ufuk
dc.institutionauthorKoç, Ahmet
dc.institutionauthorBilir, Bülent
dc.institutionauthorEmir, Seyfi
dc.language.isoen
dc.publisherInt College Of Surgeons
dc.relation.ispartofInternational Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnastomosis
dc.subjectAnastomotic leaks
dc.subjectNigella sativa
dc.subjectIschemia/reperfusion injury
dc.subjectIschemia-Reperfusion Injury
dc.subjectMucosal Lesion
dc.subjectTissue-Damage
dc.subjectOil
dc.subjectLeakage
dc.subjectThymoquinone
dc.subjectModulation
dc.subjectPrevention
dc.titleProtective Effect of Nigella Sativa in an Animal Model of Colon Anastomosis With Ischemia/Reperfusion Injury
dc.typeArticle

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