Effect of panretinal photocoagulation on retina and choroid in diabetic retinopathy: An optical coherence tomography angiography study

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dc.authoridAkarsu Acar, Özge Pinar/0000-0003-4424-2215
dc.contributor.authorAcar, Özge Pınar Akarsu
dc.contributor.authorOnur, İsmail Umut
dc.date.accessioned2023-05-06T17:22:11Z
dc.date.available2023-05-06T17:22:11Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: To analyze the quantitative changes in both macular, and choroidal thickness, and micro-vascularization after panretinal photocoagulation (PRP) in eyes with proliferative diabetic retinopathy (PDR) or severe non-proliferative diabetic retinopathy (NPDR) by using optical coherence tomography angiography (OCT-A).Methods: The patients diagnosed with severe NPDR or PDR according to the Early Treatment Diabetic Reti-nopathy Study (ETDRS) and decided to be treated with PRP were included in this prospective and observational study. Ten eyes of 10 patients with PDR and twelve eyes of 12 patients with severe NPDR were examined. Macular scans (6 x 6 mm) were obtained from OCT-A at baseline and at month 6 after PRP. Subfoveal choroidal thickness (SFCT) measurements that were obtained through the foveolar center on a high-definition line scan were recorded.Results: Best-corrected visual acuity (BCVA) significantly decreased (p = 0.018), central foveal thickness and mean parafoveal thickness significantly increased (p < 0001 and p < 0.001, respectively) six months after PRP. The thickness of all parafoveal retinal quadrants (temporal, superior, nasal, inferior) increased (p = 0.001, p = 0.003, p < 0.001, p < 0.001, respectively) and mean parafoveal, parafoveal temporal, and parafoveal nasal vessel density of the deep capillary plexus (DCP) significantly decreased six months after PRP compared with the baseline values (p = 0.023, p = 0.041, p = 0.018, respectively).Conclusions: The parafoveal vessel density of DCP decreased significantly 6 months after PRP in eyes with PDR or severe NPDR. While the difference in SFCT and choroidal flow density was not significant from the baseline; central and parafoveal retinal thickness increased and BCVA decreased significantly 6 months after PRP treatment.
dc.identifier.doi10.1016/j.pdpdt.2022.103166
dc.identifier.issn1572-1000
dc.identifier.issn1873-1597
dc.identifier.pmid36261094
dc.identifier.scopus2-s2.0-85140327227
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.pdpdt.2022.103166
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12097
dc.identifier.volume40
dc.identifier.wosWOS:000880634700004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAcar, Özge Pınar Akarsu
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofPhotodiagnosis And Photodynamic Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDiabetic retinopathy
dc.subjectPanretinal photocoagulation
dc.subjectOptical coherence tomography angiography
dc.subjectVessel density
dc.subjectChoroidal thickness
dc.subjectBlood-Flow
dc.subjectMacular Thickness
dc.subjectNonperfusion
dc.titleEffect of panretinal photocoagulation on retina and choroid in diabetic retinopathy: An optical coherence tomography angiography study
dc.typeArticle

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