Microwave-Assisted Synthesis of 5-Substituted 3-Amino-1,2,4-triazoles from Aminoguanidine Bicarbonate and Carboxylic Acids

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dc.authoridGumus, Mustafa Kemal/0000-0001-6373-5221
dc.authoridGorobets, Nikolay/0000-0001-8089-4646
dc.authoriduludag, Nesimi/0000-0002-2819-3612
dc.contributor.authorGumus, Mustafa Kemal
dc.contributor.authorGorobets, Mykola Yu.
dc.contributor.authorUludag, Nesimi
dc.date.accessioned2024-10-29T17:59:26Z
dc.date.available2024-10-29T17:59:26Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesien_US
dc.description.abstractThe effect of the molar ratio between reagents, reaction time and temperature on the yield of 5-substituted 3-amino-1,2,4-triazoles obtained by the direct condensation of carboxylic acids with aminoguanidine bicarbonate under acid catalysis conditions was studied. As a result, a general green straightforward synthesis of the title compounds bearing aliphatic substituents or a phenyl ring was developed using sealed reaction vials under controlled microwave synthesis conditions that are suitable for the application of volatile starting carboxylic acids. Our straightforward synthetic method proposed in this work increases the synthetic accessibility of these widely used building blocks and therefore is able to significantly expand the structural diversity of compounds containing a triazole moiety for the needs of drug discovery.en_US
dc.description.sponsorshipArtvin Coruh University research projecten_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.3390/pr12030573
dc.identifier.issn2227-9717
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85189147171en_US
dc.identifier.urihttps://doi.org/10.3390/pr12030573
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14733
dc.identifier.volume12en_US
dc.identifier.wosWOS:001192646000001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofProcessesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectaminoguanidineen_US
dc.subject3-amino-1,2,4-triazolesen_US
dc.subjectcarboxylic acidsen_US
dc.subjectmicrowave-assisted synthesisen_US
dc.titleMicrowave-Assisted Synthesis of 5-Substituted 3-Amino-1,2,4-triazoles from Aminoguanidine Bicarbonate and Carboxylic Acidsen_US
dc.typeArticleen_US

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