Cutaneous reactions after COVID-19 vaccination in Turkey: A multicenter study

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dc.authoridsolak, eda öksüm/0000-0002-1362-7801
dc.authoridTürkmen, Dursun/0000-0001-9076-4669
dc.authoridSavas Erdogan, Sevil/0000-0002-4392-4671
dc.authorscopusid14420760600
dc.authorscopusid57216375492
dc.authorscopusid57804889800
dc.authorscopusid23988616500
dc.authorscopusid47562309000
dc.authorscopusid55924234900
dc.authorscopusid57191339374
dc.authorwosidsolak, eda öksüm/AAN-3665-2021
dc.authorwosidTürkmen, Dursun/ABG-3801-2020
dc.contributor.authorCebeci Kahraman, Filiz
dc.contributor.authorSavaş Erdoğan, Sevil
dc.contributor.authorAktaş, Nurhan Döner
dc.contributor.authorAlbayrak, Hülya
dc.contributor.authorTürkmen, Dursun
dc.contributor.authorBorlu, Murat
dc.contributor.authorYılmaz, Ertan
dc.date.accessioned2023-04-20T08:01:13Z
dc.date.available2023-04-20T08:01:13Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıkları Ana Bilim Dalı
dc.description.abstractObjectives In this study covering all of Turkey, we aimed to define cutaneous and systemic adverse reactions in our patient population after COVID-19 vaccination with the Sinovac/CoronaVac (inactivated SARS-CoV-2) and Pfizer/BioNTech (BNT162b2) vaccines. Methods This prospective, cross-sectional study included individuals presenting to the dermatology or emergency outpatient clinics of a total of 19 centers after having been vaccinated with the COVID-19 vaccines. Systemic, local injection site, and non-local cutaneous reactions after vaccination were identified, and their rates were determined. Results Of the 2290 individuals vaccinated between April 15 and July 15, 2021, 2097 (91.6%) received the CoronaVac vaccine and 183 (8%) BioNTech. Systemic reactions were observed at a rate of 31.0% after the first CoronaVac dose, 31.1% after the second CoronaVac dose, 46.4% after the first BioNTech dose, and 46.2% after the second BioNTech dose. Local injection site reactions were detected at a rate of 35.6% after the first CoronaVac dose, 35.7% after the second CoronaVac dose, 86.9% after the first BioNTech dose, and 94.1% after the second BioNTech dose. A total of 133 non-local cutaneous reactions were identified after the CoronaVac vaccine (2.9% after the first dose and 3.5% after the second dose), with the most common being urticaria/angioedema, pityriasis rosea, herpes zoster, and maculopapular rash. After BioNTech, 39 non-local cutaneous reactions were observed to have developed (24.8% after the first dose and 5% after the second dose), and the most common were herpes zoster, delayed large local reaction, pityriasis rosea, and urticaria/angioedema in order of frequency. Existing autoimmune diseases were triggered in 2.1% of the patients vaccinated with CoronaVac and 8.2% of those vaccinated with BioNTech. Conclusions There are no comprehensive data on cutaneous adverse reactions specific to the CoronaVac vaccine. We determined the frequency of adverse reactions from the dermatologist's point of view after CoronaVac and BioNTech vaccination and identified a wide spectrum of non-local cutaneous reactions. Our data show that CoronaVac is associated with less harmful reactions while BioNTech may result in more serious reactions, such as herpes zoster, anaphylaxis, and triggering of autoimmunity. However, most of these reactions were self-limiting or required little therapeutic intervention.
dc.identifier.doi10.1111/jocd.15209
dc.identifier.endpage3703
dc.identifier.issn1473-2130
dc.identifier.issn1473-2165
dc.identifier.issue9en_US
dc.identifier.pmid35780311
dc.identifier.scopus2-s2.0-85134228318
dc.identifier.scopusqualityQ2
dc.identifier.startpage3692
dc.identifier.urihttps://doi.org/10.1111/jocd.15209
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10802
dc.identifier.volume21
dc.identifier.wosWOS:000827105400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlbayrak, Hülya
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Cosmetic Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleCutaneous reactions after COVID-19 vaccination in Turkey: A multicenter study
dc.typeArticle

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