Detection of subclinical atherosclerosis and diastolic dysfunction in patients with schizophrenia

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dc.authorscopusid26432848600
dc.authorscopusid55881189500
dc.authorscopusid55212351200
dc.authorscopusid6505680586
dc.authorscopusid36610957000
dc.authorscopusid55565751700
dc.authorscopusid37058172000
dc.authorwosidArslan, Mehtap/AAW-1045-2021
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.contributor.authorÜnsal, Cüneyt
dc.contributor.authorOran, Mustafa
dc.contributor.authorOktay Türeli, Hande
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorYeşilyurt, Sema
dc.contributor.authorArslan, Mehtap
dc.contributor.authorKurt, Erhan
dc.date.accessioned2022-05-11T14:10:06Z
dc.date.available2022-05-11T14:10:06Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractBackground: Patients with schizophrenia have a higher risk for cardiovascular diseases, which is associated with early mortality compared with the nonschizophrenic population. Early diagnosis of cardiovascular diseases in asymptomatic periods in patients with schizophrenia would enhance their quality of life and reduce mortality. Echocardiography, carotid ultrasonography, and ankle brachial index (ABI) measurement are known to be beneficial methods of detecting subclinical cardiovascular diseases and of risk stratification. The present study investigated carotid intima media thickness (CIMT) and ABI and echocardiographic parameters measured via conventional and tissue Doppler echocardiography in patients with schizophrenia in comparison with a control group. Methods: The present case-control study included 116 patients with schizophrenia and 88 healthy patients. Participants with any current comorbid psychiatric disorder, current or lifetime neurological and medical problems, current coronary artery disease, diabetes, hypertension, hypothyroidism, or hyperthyroidism or who were using antihypertensives, antidiabetic agents, or antiobesity drugs were excluded. High-resolution B-mode ultrasound images were used to measure CIMT. Conventional and tissue Doppler measurements were performed according to the recommendations of the American Society of Echocardiography. Results: Low ABI, mitral ratio of the early (E) to late (A) ventricular filling velocities, septal E', septal S', lateral E', lateral S', septal E'/septal A', lateral E'/lateral A', and high septal A', mitral E/septal E', mitral E/lateral E', and CIMT values were observed in the schizophrenia group compared with the control group. Conclusion: Doppler parameters supported the hypothesis that patients with schizophrenia are at high risk for cardiovascular diseases.
dc.identifier.doi10.2147/NDT.S52030
dc.identifier.endpage1537
dc.identifier.issn1178-2021
dc.identifier.pmid24143102
dc.identifier.scopus2-s2.0-84885461144
dc.identifier.scopusqualityQ2
dc.identifier.startpage1531
dc.identifier.urihttps://doi.org/10.2147/NDT.S52030
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5284
dc.identifier.volume9
dc.identifier.wosWOS:000325245500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÜnsal, Cüneyt
dc.institutionauthorOran, Mustafa
dc.institutionauthorAlpsoy, Şeref
dc.language.isoen
dc.publisherDove Medical Press Ltd
dc.relation.ispartofNeuropsychiatric Disease and Treatment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectschizophrenia
dc.subjectcarotid intima media thickness
dc.subjectankle brachial index
dc.subjecttissue Doppler chocardiography
dc.subjectIntima-Media Thickness
dc.subjectAnkle-Brachial Index
dc.subjectTissue Doppler-Echocardiography
dc.subjectVentricular Ejection Fraction
dc.subjectCardiovascular Risk-Factors
dc.subjectExcess Mortality
dc.subjectPhysical Health
dc.subjectDisease
dc.subjectPeople
dc.subjectMetaanalysis
dc.titleDetection of subclinical atherosclerosis and diastolic dysfunction in patients with schizophrenia
dc.typeArticle

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