Comparison of the prophylactic use of ibandronate and its use in early-stage osteonecrosis in rats with steroid-induced osteonecrosis of the femoral head

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dc.contributor.authorÇağlar, Sever
dc.contributor.authorDaşçı, Mustafa Fatih
dc.contributor.authorAcar, Abdurrahman
dc.contributor.authorÇağlar, Aysel
dc.contributor.authorDinçel, Yaşar Mahsut
dc.contributor.authorÇataltepe, Aziz
dc.date.accessioned2024-10-29T17:55:12Z
dc.date.available2024-10-29T17:55:12Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractObjectives: The aim of this study was to investigate the effects of ibandronate before and after the onset of osteonecrosis in rats with steroid-induced osteonecrosis of the femoral head. Materials and methods: A total of 24 female Sprague-Dawley rats were used in this study. Three groups were formed with eight rats in each group. The first group was the prophylactic group that received ibandronate treatment before and after the onset of osteonecrosis (Group PT). The second group received ibandronate treatment three weeks after the development of osteonecrosis (Group TAO). The third group was the control group in which osteonecrosis was created, but only normal saline (NS) was given. At the end of the study, all rats were sacrificed, and their right femoral heads were removed, fixed with formalin, and sent for micro-computed tomography. Hematoxylin-eosin (H&E) and immunohistochemical examinations of the right femoral head sections were performed. Results: In the PT group, the trabecular thickness was significantly higher compared to those of the TAO and control groups (p
dc.identifier.doi10.52312/jdrs.2023.1096
dc.identifier.endpage650
dc.identifier.issn2687-4784
dc.identifier.issn2687-4792
dc.identifier.issue3en_US
dc.identifier.startpage640
dc.identifier.trdizinid1227265
dc.identifier.urihttps://doi.org/10.52312/jdrs.2023.1096
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1227265
dc.identifier.urihttps://hdl.handle.net/20.500.11776/13879
dc.identifier.volume34
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofJoint diseases and related surgery
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRat
dc.subjectBisphosphonate
dc.subjectosteonecrosis
dc.subjectfemoral head
dc.subjectibandronate
dc.titleComparison of the prophylactic use of ibandronate and its use in early-stage osteonecrosis in rats with steroid-induced osteonecrosis of the femoral head
dc.typeArticle

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