Effect of Tadalafil on Prevention of Urethral Stricture After Urethral Injury: An Experimental Study

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dc.authorid0000-0001-6140-5181
dc.authorscopusid57216014831
dc.authorscopusid56615123900
dc.authorscopusid8416588900
dc.authorscopusid24436194200
dc.authorscopusid56084894100
dc.authorscopusid57105635700
dc.authorwosidYazici, Cenk Murat/AAA-4330-2020
dc.authorwosidÖZÇAĞLAYAN, ÖMER/ABA-4293-2020
dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorKurt, Ömer
dc.contributor.authorYeşildağ, Ebru
dc.contributor.authorYazıcı, Cenk Murat
dc.contributor.authorAktaş, Cevat
dc.contributor.authorÖzçağlayan, Ömer
dc.contributor.authorBozdemir, Yeliz
dc.date.accessioned2022-05-11T14:07:43Z
dc.date.available2022-05-11T14:07:43Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Çocuk Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.description.abstractOBJECTIVE To evaluate the preventive effect of phosphodiesterase type 5 inhibitor (tadalafil) on the formation of urethral stricture after urethral injury. MATERIALS AND METHODS A total of 28, 4-month-old male New Zealand rabbits were included and divided into 3 groups. Group 1 was a sham group with 8 rabbits that underwent only urethroscopy. Group 2 was a nontreatment group with 10 rabbits that underwent urethral electrocoagulation without any treatment. Group 3 was the treatment group with 10 rabbits that underwent urethral electrocoagulation with systemic tadalafil treatment. After 30 days of follow-up, urethroscopy and retrograde urethrography were performed to evaluate the morphological changes in the urethra. The urethra tissues were examined with standard light microscopy by a histologist, and apoptosis was evaluated by the terminal dUTP nick end-labeling assay. RESULTS Urethral diameters in group 1, group 2, and group 3 were 9.14 +/- 0.73 mm, 3.52 +/- 1.2 mm, and 7.68 +/- 1.14 mm, respectively. The differences in urethral diameters were statistically significant between groups (P < .01). Collagen deposition in submucosal connective tissue was significantly less in the tadalafil group vs the nontreatment group. The numbers of apoptotic cells in submucosal connective tissue were also quantitatively higher in urethral stricture groups compared to the sham group. CONCLUSION Tadalafil treatment had a protective effect against the formation of urethral stricture in rabbit model. This treatment can be a promising opportunity for urethral stricture and must be supported by clinical studies. (C) 2016 Elsevier Inc.
dc.identifier.doi10.1016/j.urology.2016.02.034
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.pmid26948527
dc.identifier.scopus2-s2.0-84964381166
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.urology.2016.02.034
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5183
dc.identifier.volume91
dc.identifier.wosWOS:000375901500075
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKurt, Ömer
dc.institutionauthorYeşildağ, Ebru
dc.institutionauthorYazıcı, Cenk Murat
dc.institutionauthorAktaş, Cevat
dc.institutionauthorÖzçağlayan, Ömer
dc.institutionauthorBozdemir, Yeliz
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofUrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNitric-Oxide Synthase
dc.subjectPhosphodiesterase Inhibition
dc.subjectInternal Urethrotomy
dc.subjectRabbit Model
dc.subjectRat Model
dc.subjectIn-Vitro
dc.subjectSildenafil
dc.subjectActivation
dc.subjectDisease
dc.subjectHalofuginone
dc.titleEffect of Tadalafil on Prevention of Urethral Stricture After Urethral Injury: An Experimental Study
dc.typeArticle

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