Predictive Value of Serum Calprotectin Level in Response to Treatment, a New Inflammatory Marker in Patients with Breast Cancer Requesting Neoadjuvant Treatment

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dc.authoridCELIKKOL, ALIYE/0000-0002-3799-4470
dc.authoridSEBER, SELCUK/0000-0001-9081-2405
dc.contributor.authorBaydar, Ece
dc.contributor.authorCelikkol, Aliye
dc.contributor.authorGurdal, Sibel Ozkan
dc.contributor.authorSeber, Selcuk
dc.date.accessioned2024-10-29T17:59:36Z
dc.date.available2024-10-29T17:59:36Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractAim: There is a close relationship between inflammation and cancer. Calprotectin is a protein released during inflammation. The aim of this study is to investigate the relationship between breast cancer and calprotectin levels in breast cancer patients receiving neoadjuvant therapy the predictive role of calprotectin in response to treatment. Materials and Methods: In our prospective study, a patient group with 69 breast cancer patients and a control group with 20 patients were formed. Calprotectin was studied from the blood tests taken from the whole sample. Patient data were obtained from the electronic record system. In our study, statistical evaluations were made using a package program called IBM Statistical Package for the Social Sciences Statistics 24. Results: Eighty-nine patients (69 cancer, 20 controls) were included in the study. The median age of breast cancer patients was 48 [minimum (min): 24-maximum (max): 73], the control group was 44.5 (min: 19-max: 68) and the ages of the two groups were similar (p=0.599). Mean calprotectin levels in breast cancer patients were 28.63 +/- 30.5, median 16.5 (min: 6.7-max: 160.7). The mean in the control group was 16.09 +/- 6.1 (min: 8.7-max: 27.4) and there was no statistical difference between the 2 groups (p=0.072). A statistically significant difference was found in terms of calprotectin values according to Ki67 classes (Z=-20.043; p=0.041). Calprotectin values of those with Ki67 class >20 were statistically significantly higher than those with <= 20. Parameters that could predict complete chemotherapy response were evaluated with logistic regression analysis. There was no correlation between calprotectin level and complete response. There was a positive correlation between age increase and complete response. Conclusion: There was no significant difference between serum calprotectin levels of the patient and control groups, but calprotectin level was found to be associated with Ki67 level. There was no relationship between calprotectin and chemotherapy response. Studies with larger sample numbers may make a significant difference.
dc.identifier.doi10.4274/nkmj.galenos.2023.61587
dc.identifier.endpage16
dc.identifier.issn2587-0262
dc.identifier.issue1en_US
dc.identifier.startpage12
dc.identifier.trdizinid#BAŞV!
dc.identifier.urihttps://doi.org/10.4274/nkmj.galenos.2023.61587
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1175788
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14784
dc.identifier.volume11
dc.identifier.wosWOS:001186705700012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofNamik Kemal Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBreast cancer
dc.subjectserum calprotectin
dc.subjectinflammation
dc.subjectcomplete response
dc.titlePredictive Value of Serum Calprotectin Level in Response to Treatment, a New Inflammatory Marker in Patients with Breast Cancer Requesting Neoadjuvant Treatment
dc.title.alternativeNeoadjuvan Tedavi Alan Meme Kanserli Hastalarda Yeni Bir Enflamatuvar Belirteç Olan Serum Kalprotektin Düzeyinin Tedaviye Yanıtta Prediktif Değeri
dc.typeArticle

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