ROI-based analysis of diffusion indices in healthy subjects and subjects with deficit or non-deficit syndrome schizophrenia

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dc.authoridKuskun, Atakan/0000-0001-6559-5322
dc.authoridDevecioglu, Ismail/0000-0003-4119-617X
dc.contributor.authorTurk, Yasar
dc.contributor.authorDevecioglu, Ismail
dc.contributor.authorKuskun, Atakan
dc.contributor.authorOge, Cem
dc.contributor.authorBeyazyuz, Elmas
dc.contributor.authorAlbayrak, Yakup
dc.date.accessioned2024-10-29T17:58:28Z
dc.date.available2024-10-29T17:58:28Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractWe analyzed DTI data involving 22 healthy subjects (HC), 15 patients with deficit syndrome schizophrenia (DSZ), and 25 patients with non-deficit syndrome schizophrenia (NDSZ). We used a 1.5-T MRI scanner to collect diffusion-weighted images and T1 images, which were employed to correct distortions and deformations within the diffusion-weighted images. For 156 regions of interest (ROI), we calculated the average fractional anisotropy (FA), mean diffusion (MD), and radial diffusion (RD). Each ROI underwent a group-wise comparison using permutation F-test, followed by post hoc pairwise comparisons with Bonferroni correction. In general, we observed lower FA in both schizophrenia groups compared to HC (i.e., HC>(DSZ=NDSZ)), while MD and RD showed the opposite pattern. Notably, specific ROIs with reduced FA in schizophrenia patients included bilateral nucleus accumbens, left fusiform area, brain stem, anterior corpus callosum, left rostral and caudal anterior cingulate, right posterior cingulate, left thalamus, left hippocampus, left inferior temporal cortex, right superior temporal cortex, left pars triangularis and right lingual gyrus. Significantly, the right cuneus exhibited lower FA in the DSZ group compared to other groups ((HC=NDSZ)>DSZ), without affecting MD and RD. These results indicate that compromised neural integrity in the cuneus may contribute to the pathophysiological distinctions between DSZ and NDSZ.
dc.description.sponsorshipTekirdag Namimath;k Kemal University [NKUBAP.02.GA.18.17]
dc.description.sponsorshipThis study is supported by Tekirdag Nam & imath;k Kemal University grant no: NKUBAP.02.GA.18.17.
dc.identifier.doi10.1016/j.pscychresns.2023.111726
dc.identifier.issn0925-4927
dc.identifier.issn1872-7506
dc.identifier.pmid37925764
dc.identifier.scopus2-s2.0-85175611235
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.pscychresns.2023.111726
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14338
dc.identifier.volume336
dc.identifier.wosWOS:001110981700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofPsychiatry Research-Neuroimaging
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDeficit syndrome schizophrenia
dc.subjectDiffusion tensor imaging
dc.subjectDiffusivity
dc.subjectFractional anisotropy
dc.subjectNondeficit syndrome schizophrenia
dc.subjectROI-based analysis
dc.subjectSchizophrenia
dc.titleROI-based analysis of diffusion indices in healthy subjects and subjects with deficit or non-deficit syndrome schizophrenia
dc.typeArticle

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