Hawthorn Vinegar in Health with a Focus on Immune Responses

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dc.authoridYikmis, Seydi/0000-0001-8694-0658
dc.authoridKarakci, Deniz/0000-0002-1884-1874
dc.authoridSeyidoglu, Nilay/0000-0002-2817-5131
dc.contributor.authorSeyidoglu, Nilay
dc.contributor.authorKarakci, Deniz
dc.contributor.authorBakir, Buket
dc.contributor.authorYikmis, Seydi
dc.date.accessioned2024-10-29T17:59:25Z
dc.date.available2024-10-29T17:59:25Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractBackground: The hawthorn fruit is an interesting medicinal plant that has several biological features, especially related to anti-inflammatory, antioxidant and immune-modulating actions, and boosting general health. In this study, we aimed to clarify the immunological effects of hawthorn vinegar on immunity and general health. We also focused on three different production processes to improve the antioxidant activity of hawthorn vinegar (2) Methods: In the study, besides the traditional production of hawthorn vinegar (N), thermal pasteurization (P) and ultrasound (U) techniques were applied to vinegars. A total of 56 female adult Wistar albino rats were randomly allocated into seven groups; Control, N0.5 (regular vinegar; 0.5 mL/kgbw), N1 (regular vinegar; 1 mL/kgbw), P0.5 (pasteurized vinegar; 0.5 mL/kgbw), P1 (pasteurized vinegar; 1 mL/kgbw), U0.5 (ultrasound treated vinegar; 0.5 mL/kgbw), and U1 (ultrasound treated vinegar; 1 mL/kgbw). Vinegars were administered by oral gavage daily. The average weight gains, body mass index, and blood hematological parameters were measured, and the Neutrophil Lymphocyte ratio was calculated. The plasma IL-1 beta and TNF-alpha values, and MDA, IL-1 beta and TNF-alpha values of intestinal tissue, were determined. Also, the streptavidin-biotin-peroxidase complex method was applied to determine the expressions of TNF-alpha and IL-1 beta in duodenum. (3) Results: There was a decreasing tendency in the average weight gains in all vinegar groups compared to the control group. In addition, there was an increase in NL ratio in all vinegar groups, although not significant. There were no statistical differences among all vinegar groups, although decreases were observed in plasma IL-1 beta. Also, the plasma TNF-alpha values showed slight increases in high-dose-of-vinegar groups (N1, P1 and U1), although not significant. In addition, the intestinal tissue IL-1 beta value tended to increase in groups N0.5, N1 and P0.5, while it tended to decrease in P1, U0.5 and U1. On the other hand, there were slight increases in the TNF-alpha values of intestinal tissue in all groups compared to control, although these were not significant. Furthermore, the intensive expressions of TNF-alpha and IL-1 beta were determined in groups U0.5 and U1. (4) Conclusions: The results suggest that either high doses or ultrasound applications of hawthorn vinegar have positive effects on intestinal health, boosting immunity and general health.
dc.description.sponsorshipResearch Foundations of Tekirdag Namik Kemal University [NKUBAP.10.GA.21.346]
dc.description.sponsorshipThis study was supported by a grant from the Research Foundations of Tekirdag Namik Kemal University (Project number: NKUBAP.10.GA.21.346).
dc.identifier.doi10.3390/nu16121868
dc.identifier.issn2072-6643
dc.identifier.issue12en_US
dc.identifier.pmid38931223
dc.identifier.scopus2-s2.0-85197144042
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/nu16121868
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14729
dc.identifier.volume16
dc.identifier.wosWOS:001255856500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofNutrients
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthawthorn
dc.subjecthawthorn vinegar
dc.subjectrat
dc.subjectultrasound-treated
dc.titleHawthorn Vinegar in Health with a Focus on Immune Responses
dc.typeArticle

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