Possible association between vitamin D deficiency and restless legs syndrome

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dc.authorscopusid55881189500
dc.authorscopusid26432848600
dc.authorscopusid29067508300
dc.authorscopusid8514414100
dc.authorscopusid55976452800
dc.authorscopusid56082620300
dc.authorscopusid6603040523
dc.authorwosidAlbayrak, Yakup/ABA-7651-2020
dc.authorwosidAvcı, Okan/ABG-8782-2021
dc.contributor.authorOran, Mustafa
dc.contributor.authorÜnsal, Cüneyt
dc.contributor.authorAlbayrak, Yakup
dc.contributor.authorTülübaş, Feti
dc.contributor.authorOğuz, Keriman
dc.contributor.authorAvcı, Okan
dc.contributor.authorGürel, Ahmet
dc.date.accessioned2022-05-11T14:07:42Z
dc.date.available2022-05-11T14:07:42Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractBackground and aim: Restless legs syndrome (RLS) is a distressing sleep disorder that occurs worldwide. Although there have been recent developments in understanding the -pathophysiology of RLS, the exact mechanism of the disease has not been well elucidated. An increased prevalence of neurologic and psychiatric diseases involving dopaminergic dysfunction in vitamin D-deficient patients led us to hypothesize that vitamin D deficiency might result in dopaminergic dysfunction and consequently, the development of RLS (in which dopaminergic dysfunction plays a pivotal role). Thus, the aim of this study was to evaluate the relationship between vitamin D deficiency and RLS. Methods: One hundred and fifty-five consecutive patients, 18-65 years of age, who were admitted to the Department of Internal Medicine with musculoskeletal symptoms and who subsequently underwent neurological and electromyography (EMG) examination by the same senior neurologist, were included in this study. The patients were divided into two groups according to serum 25-hydroxyvitamin D (25(OH) D) (a vitamin D metabolite used as a measure of vitamin D status) level: 36 patients with serum 25(OH) D levels. 20 ng/mL comprised the normal vitamin D group, and 119 patients with serum 25(OH) D levels >= 20 ng/mL comprised the vitamin D deficiency group. The two groups were compared for the presence of RLS and associated factors. Results: The two groups were similar in terms of mean age, sex, mean body mass index (BMI), and serum levels of calcium, phosphate, alkaline phosphatase (ALP), and ferritin. The presence of RLS was significantly higher in the vitamin D deficiency group (chi(2)=12.87, P<0.001). Regression analysis showed vitamin D deficiency and serum 25(OH) D level to be significantly associated with the presence of RLS (odds ratio [OR] 5.085, P<0.001 and OR 1.047, P=0.006, respectively). Conclusion: The present study demonstrated a possible association between vitamin D -deficiency and RLS. Given the dopaminergic effects of vitamin D, 25(OH) D depletion may lead to dopaminergic dysfunction and may have a place in the etiology of RLS. Prospective vitamin D treatment studies are needed to confirm this relationship and to evaluate the efficacy of vitamin D as a treatment for RLS patients.
dc.identifier.doi10.2147/NDT.S63599
dc.identifier.endpage958
dc.identifier.issn1178-2021
dc.identifier.pmid24899811
dc.identifier.scopus2-s2.0-84901476094
dc.identifier.scopusqualityQ2
dc.identifier.startpage953
dc.identifier.urihttps://doi.org/10.2147/NDT.S63599
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5180
dc.identifier.volume10
dc.identifier.wosWOS:000336445000002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOran, Mustafa
dc.institutionauthorÜnsal, Cüneyt
dc.institutionauthorAlbayrak, Yakup
dc.institutionauthorTülübaş, Feti
dc.institutionauthorOğuz, Keriman
dc.institutionauthorAvcı, Okan
dc.institutionauthorGürel, Ahmet
dc.language.isoen
dc.publisherDove Medical Press Ltd
dc.relation.ispartofNeuropsychiatric Disease and Treatment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject25 hydroxyvitamin D
dc.subjectdopamine
dc.subjectdysfunction
dc.subject1,25-Dihydroxyvitamin D-3
dc.subjectBrain Iron
dc.subjectGlutathione
dc.subjectDiagnosis
dc.subjectDisease
dc.titlePossible association between vitamin D deficiency and restless legs syndrome
dc.typeArticle

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