Beneficial Effects of Ibuprofen on Pentylenetetrazol-induced Convulsion

Basit Öğe Kaydı
dc.authorscopusid55315126400
dc.authorscopusid55175886400
dc.authorscopusid57218290288
dc.authorscopusid29067508300
dc.authorscopusid27967486000
dc.authorscopusid57216297567
dc.authorscopusid55469991100
dc.contributor.authorDurankuş, Ferit
dc.contributor.authorŞenkal, E.
dc.contributor.authorSünnetçi, E.
dc.contributor.authorAlbayrak, Yakup
dc.contributor.authorBeyazyüz, Murat
dc.contributor.authorAtasoy, Ö.
dc.contributor.authorErbaş, O.
dc.date.accessioned2022-05-11T14:05:08Z
dc.date.available2022-05-11T14:05:08Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractIbuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used as an anti-inflammatory, anti-pyretic, and analgesic. Although some studies have focused on the anti-inflammatory and anti-pyretic properties of ibuprofen during febrile convulsions, only one has investigated its antiepileptic effects. In the present study, we aimed to investigate the effects of ibuprofen in rats exposed to pentylenetetrazol (PTZ)-induced seizures. In total, 48 rats were randomly divided in two groups: Group A for electroencephalography (EEG) recordings and Group B for behavioral assessment. All EEG recordings and behavioral assessment protocols were performed. In addition, groups were compared in terms of prostaglandin F2 alfa (PGF2?) levels in the brain. We demonstrated the beneficial effects of the administration of ibuprofen in PTZ-induced seizures in rats via the following findings: spike percentages and Racine convulsion scale values were significantly lower and first myoclonic jerk (FMJ) onset times were significantly higher in the ibuprofen-administered groups. Moreover, PGF2? levels in the brain were significantly higher in the saline and PTZ 70 mg/kg group than in the control and PTZ 70 mg/kg and 400 mg/kg ibuprofen groups. Our study is the first to demonstrate the beneficial effects of ibuprofen on seizures through behavioral, EEG, and PGF2? brain assessments. Ibuprofen can be used for epilepsy and febrile seizures safely and without inducing seizures. However, further experimental and clinical studies are needed to confirm our results. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
dc.identifier.doi10.1007/s11064-020-03101-3
dc.identifier.endpage2416
dc.identifier.issn0364-3190
dc.identifier.issue10en_US
dc.identifier.pmid32719978
dc.identifier.scopus2-s2.0-85088660508
dc.identifier.scopusqualityQ1
dc.identifier.startpage2409
dc.identifier.urihttps://doi.org/10.1007/s11064-020-03101-3
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4902
dc.identifier.volume45
dc.identifier.wosWOS:000553577100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlbayrak, Yakup
dc.institutionauthorBeyazyüz, Murat
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofNeurochemical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEpilepsy
dc.subjectFebrile
dc.subjectIbuprofen
dc.subjectSeizure
dc.subjectTreatment
dc.subjectibuprofen
dc.subjectpentetrazole
dc.subjectprostaglandin F2 alpha
dc.subjectanticonvulsive agent
dc.subjectibuprofen
dc.subjectprostaglandin F2 alpha
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbrain
dc.subjectbrain tissue
dc.subjectcontrolled study
dc.subjectdrug megadose
dc.subjectelectroencephalography
dc.subjectenzyme linked immunosorbent assay
dc.subjectfrontal cortex
dc.subjectlow drug dose
dc.subjectmale
dc.subjectmyoclonus
dc.subjectnonhuman
dc.subjectpentylenetetrazole-induced convulsion
dc.subjectpriority journal
dc.subjectrat
dc.subjectrighting reflex
dc.subjecttonic clonic seizure
dc.subjectanimal
dc.subjectmetabolism
dc.subjectmyoclonus
dc.subjectseizure
dc.subjectSprague Dawley rat
dc.subjectAnimals
dc.subjectAnticonvulsants
dc.subjectDinoprost
dc.subjectIbuprofen
dc.subjectMale
dc.subjectMyoclonus
dc.subjectPentylenetetrazole
dc.subjectRats, Sprague-Dawley
dc.subjectSeizures
dc.titleBeneficial Effects of Ibuprofen on Pentylenetetrazol-induced Convulsion
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
4902.pdf
Boyut:
1.01 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu