The Diagnostic Utility of Flow Cytometry in Celiac Disease Presented Isolated Iron Deficiency Anemia

Basit Öğe Kaydı
dc.authorscopusid36608599700
dc.authorscopusid55881189500
dc.authorscopusid55858848900
dc.authorscopusid6701664192
dc.contributor.authorMete, Rafet
dc.contributor.authorOran, Mustafa
dc.contributor.authorAvcı, Burcu Altındağ
dc.contributor.authorTurgut, Burhan
dc.date.accessioned2022-05-11T14:40:02Z
dc.date.available2022-05-11T14:40:02Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Flow cytometric analysis of intestinal intraepithelial lymphocytes contributes to the diagnosis of celiac disease. Celiac disease may present with iron deficiency anemia alone which is considered as one of the forms of atypical celiac disease. In this study, we have aimed to investigate the diagnostic utility of flow cytometric analysis of intraepithelial lymphocytes in this atypical form. Methods: Three groups were formed: the patients with unexplained iron deficiency (group 1), the patients with celiac disease (group 2), and the patients who underwent gastroduodenoscopy for other reasons (group 0). Duodenal biopsy samples were used for flow cytometric analysis of intraepithelial lymphocytes. T cell receptor gammadelta intraepithelial lymphocytes and CD3-/CD103+ intraepithelial lymphocytes were determined with relevant monoclonal antibodies. Sensitivity-specificity calculation was performed to evaluate the usability of flow cytometric variables as diagnostic tests. Results: Group 1 had 22 patients, group 2 had 14 patients, and group 0 had 56 patients. In the comparison of the 3 groups, CD3+/ TCR gamma delta+ intraepithelial lymphocytes were found to be higher in celiac patients than other cases. CD3+/TCR gamma delta+ intraepithelial lymphocyte was evaluated for its usability as a diagnostic test. The cut-off value of CD3+/TCR gamma delta+ intraepithelial lymphocyte as 16.39% according to receiver operating characteristics curve analysis determined celiac disease in 14 of 22 patients in group 1 with 91.7% sensitivity and 80.4% specificity. Conclusions: Although celiac disease is diagnosed with serologic tests and histologic examination, successively, the increase in intestinal CD3+/TCR gamma delta+ intraepithelial lymphocytes may be used as a diagnostic test, and it may assist in revealing atypical forms of celiac disease.
dc.description.sponsorshipCoordinatorship of Scientific Research Projects of Namik Kemal University [NKUBAP.00.20, AR.12.06]
dc.description.sponsorshipThis study was supported by Coordinatorship of Scientific Research Projects of Namik Kemal University with the project number NKUBAP.00.20.AR.12.06.
dc.identifier.doi10.5152/tjg.2020.191016
dc.identifier.endpage936
dc.identifier.issn2148-5607
dc.identifier.issue11en_US
dc.identifier.pmid34872894
dc.identifier.scopus2-s2.0-85122458570
dc.identifier.scopusqualityQ3
dc.identifier.startpage932
dc.identifier.urihttps://doi.org/10.5152/tjg.2020.191016
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8841
dc.identifier.volume32
dc.identifier.wosWOS:000727746500003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMete, Rafet
dc.institutionauthorOran, Mustafa
dc.institutionauthorAvcı, Burcu Altındağ
dc.institutionauthorTurgut, Burhan
dc.language.isoen
dc.publisherAves
dc.relation.ispartofTurkish Journal of Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAtypical celiac disease
dc.subjectiron deficiency anemia
dc.subjectflow cytometry
dc.subjectIELs
dc.subjectIntestinal Intraepithelial Lymphocytes
dc.subjectTransglutaminase
dc.subjectGuidelines
dc.subjectAntigliadin
dc.subjectManagement
dc.subjectAntibody
dc.subjectSociety
dc.titleThe Diagnostic Utility of Flow Cytometry in Celiac Disease Presented Isolated Iron Deficiency Anemia
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
8841.pdf
Boyut:
807.8 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu