Effect of short term thyroxin withdrawal on health related quality of life in differentiated thyroid carcinoma patients

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dc.authorscopusid50461202500
dc.authorscopusid55987542100
dc.authorscopusid54880546000
dc.authorscopusid56725133200
dc.authorscopusid35949526800
dc.authorscopusid56490954700
dc.authorscopusid55800400300
dc.contributor.authorElboğa, Umut
dc.contributor.authorElboga, G.
dc.contributor.authorKalender, Ebuzer
dc.contributor.authorDemir, Hasan Deniz
dc.contributor.authorŞahin, Ertan
dc.contributor.authorBaşıbüyük, Mustafa
dc.contributor.authorÖzkaya, M.
dc.date.accessioned2022-05-11T14:40:53Z
dc.date.available2022-05-11T14:40:53Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nükleer Tıp Ana Bilim Dalı
dc.description.abstractBackground: We aimed to study the HRQL in patients with differentiated thyroid carcinoma (DTC) during hypothyroidism due to thyroxin withdrawal, which is induced routinely for iodine-131 (I-131) whole body scan and ablative treatment. Methods: Between September 2011 and March 2012, eligible patients with DTC who were referred to our institution for diagnostic or therapeutic radioiodine administration under hypothyroid conditions due to thyroid hormone withdrawal were asked to complete the psychological instruments rating their HRQL and psychological status. HRQL was studied using the Short Form (SF-36), Hospital Anxiety and Depression Scale (HADS), Profile of Mood States (POMS), the total mood disturbance (TMD) score, Beck Depression Inventory (BDI).One hundred and forty three hypothyroid patients with DTC (F=101, M=42, age=58.7 yrs) who were also on low-iodine diet were included in this study. Hypothyroidism was induced by withdrawal of thyroxin replacement in all patients. Results: The results of SF-36 showed that the HRQL was significantly impaired in hypothyroid patients during withdrawal of thyroxin (physical component scale: 44.3 ± 9.5, mental component scale: 40.8 ± 10.2, p ? 0.001). Depression scores were in the normal or non-clinically relevant range: 4.1 ± 3.8 on the HADS-Depression and 8.3 ± 6.6 on the Beck Depression Index. However, the mean score of 28.8 ± 25.2 on the POMS TMD was within normal range. Conclusion: HRQL is impaired in hypothyroid patients with DTC during thyroxine withdrawal before I-131 whole body scan and radioiodine therapy. © 2015 Elboga U, et al.
dc.identifier.doi10.4172/Psychiatry.1000254
dc.identifier.issn1994-8220
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84946780454
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.4172/Psychiatry.1000254
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8951
dc.identifier.volume18
dc.indekslendigikaynakScopus
dc.institutionauthorŞahin, Ertan
dc.language.isoen
dc.publisherIn House Publications
dc.relation.ispartofAfrican Journal of Psychiatry (South Africa)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDTC
dc.subjectHRQL
dc.subjectThyroxine withdrawal
dc.subjectiodine 131
dc.subjectthyroxine
dc.subjectablation therapy
dc.subjectadult
dc.subjectage distribution
dc.subjectaged
dc.subjectArticle
dc.subjectBeck Depression Inventory
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectdepression
dc.subjectdifferentiated thyroid cancer
dc.subjectdrug withdrawal
dc.subjectfemale
dc.subjectHospital Anxiety and Depression Scale
dc.subjecthuman
dc.subjecthypothyroidism
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpatient referral
dc.subjectProfile of Mood States
dc.subjectpsychologic test
dc.subjectquality of life
dc.subjectscoring system
dc.subjectsex difference
dc.subjectShort Form 36
dc.subjecttotal mood disturbance score
dc.subjectvery elderly
dc.subjectwhole body scintiscanning
dc.titleEffect of short term thyroxin withdrawal on health related quality of life in differentiated thyroid carcinoma patients
dc.typeArticle

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