Is 25(OH)D Associated with Cognitive Impairment and Functional Improvement in Stroke? A Retrospective Clinical Study

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dc.authorid0000-0002-4003-3646
dc.authorscopusid35192520400
dc.authorscopusid37077994100
dc.authorscopusid55758320600
dc.authorscopusid55945349000
dc.authorscopusid56601176900
dc.authorscopusid56601470000
dc.authorscopusid56601310900
dc.authorwosidAkcay, Seniz/ABH-7247-2020
dc.authorwosidAfsar, Sevgi Ikbali/E-2103-2019
dc.contributor.authorAkçay Yalbuzdağ, Şeniz
dc.contributor.authorSarıfakıo?lu, Ayşe Banu
dc.contributor.authorİkbali Afşar, Sevgi
dc.contributor.authorÇelik, Canan
dc.contributor.authorCan, Aslı
dc.contributor.authorYeğin, Tuğba
dc.contributor.authorYıldırım Güzelant, Aliye
dc.date.accessioned2022-05-11T14:39:45Z
dc.date.available2022-05-11T14:39:45Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fizik Tedavi ve Rehabilitasyon Ana Bilim Dalı
dc.description.abstractBackground: In recent years, vitamin D deficiency has been suggested as a risk factor for ischemic stroke and stroke severity in both animal models and clinical studies. In this retrospective study, we investigated the relationship between 25-hydroxyvitamin D [25(OH)D] levels and functional outcomes in stroke patients during neurological rehabilitation program. We also investigated whether there is an association between 25(OH)D levels and cognitive impairment. Methods: The study included the medical records of 120 stroke patients who participated in a neurological rehabilitation program. The motor and cognitive components of the Functional Independence Measurements of all patients at admission and discharge were recorded. The Functional Ambulatory Scale was used to assess motor functional status, and the Turkish-validated version of the minimental state examination test was used to assess cognitive status. Results: A significant correlation was found between 25(OH)D level and cognitive impairment among patients who had ischemic strokes. High levels of 25(OH)D were associated with greater functional gain during the rehabilitation program in both ischemic stroke patients and hemorrhagic stroke patients. Conclusions: High 25(OH)D levels might be associated with greater functional improvement and with less cognitive impairment in stroke patients.
dc.identifier.doi10.1016/j.jstrokecerebrovasdis.2015.03.007
dc.identifier.endpage1486
dc.identifier.issn1052-3057
dc.identifier.issn1532-8511
dc.identifier.issue7en_US
dc.identifier.pmid25922112
dc.identifier.scopus2-s2.0-84930821504
dc.identifier.scopusqualityQ1
dc.identifier.startpage1479
dc.identifier.urihttps://doi.org/10.1016/j.jstrokecerebrovasdis.2015.03.007
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8696
dc.identifier.volume24
dc.identifier.wosWOS:000356049000011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSarıfakıo?lu, Ayşe Banu
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofJournal of Stroke & Cerebrovascular Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectStroke
dc.subjectvitamin D
dc.subjectrehabilitation
dc.subjectcognitive function
dc.subjectVitamin-D Deficiency
dc.subject25-Hydroxyvitamin D Predicts
dc.subject1,25-Dihydroxyvitamin D-3
dc.subjectD-Receptor
dc.subjectMessenger-Rna
dc.subjectNeurotoxicity
dc.subjectExpression
dc.subjectIschemia
dc.subjectProtects
dc.subjectHealth
dc.titleIs 25(OH)D Associated with Cognitive Impairment and Functional Improvement in Stroke? A Retrospective Clinical Study
dc.typeArticle

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