Hipertiroidili kadın hastalarda E vitamini düzeyleri ve oksidatif stres
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Dosyalar
Tarih
2009
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Hipertiroidili kadın hastalarda serbest radikallerin oluşturduğu oksidatif hasarın değerlendirilmesi ve E vitaminiyle ilişkisinin irdelenmesi amaçlandı. Gereç ve Yöntemler: Çalışma 24 hipertiroidili kadın hasta (yaş ortalaması 40.78±9.62 yıl) ve 22 ötiroidili kadın hastadan (yaş ortalamaları 42.5±10.66 yıl) oluşturuldu. Her iki grupta da E vitamini, tiyo barbitürik asitle reaksiyonlaşan maddeler (TBARS), protein karbonil grup (PCG), serbest T3, serbest T4, TSH, total kolesterol, trigliserid, LDL-kolesterol ve HDL-kolesterol düzeylerine bakıldı. Bulgular: Plazma E vitamini düzeyleri hipertiroidik hastalarda, ötiroidik kontrol grubuna göre anlamlı olarak düşük saptandı (p<0.001). TBARS ve PCG düzeyleri hipertiroidik hastalarda, ötiroidik kontrol grubuna göre anlamlı olarak yüksek saptandı (sırasıyla p<0.001, p<0.01). E vitamini düzeyleri 40 yaşın üzerindeki hipertiroidik hastalarda; 40 yaşın altındakilere göre anlamlı olarak düşük (p<0.05), TBARS ve PCG düzeyleri anlamlı olarak yüksek saptandı (sırasıyla p<0.01, p<0.05). Korelasyon analizi bulgularında hipertiroidik hasta grubunda E vitamini ile TBARS ve yaş arasında negatif korelasyon (sırasıyla r=-0.612**, r=-0.755***) ve E vitamini ile trigliserit arasında pozitif korelasyon bulundu (r=0.428*). TBARS ile PCG arasıda pozitif korelasyon saptandı (r = 0.497*). Sonuç: Hipertiroidili kadın hastalarda artan oksidatif stresin protein oksidasyonu ile lipid peroksidasyonunu tetiklediği ve bir antioksidan olan E vitamini düzeylerinde bir azalmaya neden olduğunu göstermiştir. Çalışmamızda özellikle 40 yaşın üstündeki hastaların E vitamini düzeylerinin daha düşük olarak saptanması dikkat çekicidir.
Objective: In this study, we aimed to evaluate the free radical-mediated oxidative stress and its relationship to vitamin E in women with hyperthyroidism. Material and Method: Twenty-four female patients with hyperthyroidism (mean age, 40.78±9.62 yrs) and twenty-two euthyroid female patients (mean age, 42.5±10.66 yrs) were recruited into this study. Fasting blood samples were analyzed for vitamin E, thiobarbituric acid reactive substances (TBARS), protein carbony group (PCG), free T3, free T4, TSH, total cholesterol, trigylceride, LDL-cholesterol and HDL-cholesterol levels. Results: The levels of vitamin E in patients with hyperthyroid were significantly lower compared to euthyroid control group (p<0,001). TBARS and PCG levels in hyperthyroid patients were significantly higher than the euthyroid control group (p<0.001, p<0.01, respectively). Vitamin E levels in hyperthyroid patients over age 40 were significantly lower (p<0.005) but TBARS and PCG levels were higher (p<0.01, p<0.05, respectively) than the patients below age 40. Vitamin E levels were negatively correlated with TBARS and age (r=-0.612**, r =-0.755***) respectively and positively with triglyceride level (r=0.428*) in hyperthyroid patients. In addition, TBARS was correlated positively with PCG levels (r=0.497*). Conclusion: Our study shows that increased oxidative stress in hyperthyroid women triggers protein oxidation and lipid peroxidation which a cause a decrease in vitamin E levels. Interestingly, lower levels of vitamin E were detected in patients over age 40.
Objective: In this study, we aimed to evaluate the free radical-mediated oxidative stress and its relationship to vitamin E in women with hyperthyroidism. Material and Method: Twenty-four female patients with hyperthyroidism (mean age, 40.78±9.62 yrs) and twenty-two euthyroid female patients (mean age, 42.5±10.66 yrs) were recruited into this study. Fasting blood samples were analyzed for vitamin E, thiobarbituric acid reactive substances (TBARS), protein carbony group (PCG), free T3, free T4, TSH, total cholesterol, trigylceride, LDL-cholesterol and HDL-cholesterol levels. Results: The levels of vitamin E in patients with hyperthyroid were significantly lower compared to euthyroid control group (p<0,001). TBARS and PCG levels in hyperthyroid patients were significantly higher than the euthyroid control group (p<0.001, p<0.01, respectively). Vitamin E levels in hyperthyroid patients over age 40 were significantly lower (p<0.005) but TBARS and PCG levels were higher (p<0.01, p<0.05, respectively) than the patients below age 40. Vitamin E levels were negatively correlated with TBARS and age (r=-0.612**, r =-0.755***) respectively and positively with triglyceride level (r=0.428*) in hyperthyroid patients. In addition, TBARS was correlated positively with PCG levels (r=0.497*). Conclusion: Our study shows that increased oxidative stress in hyperthyroid women triggers protein oxidation and lipid peroxidation which a cause a decrease in vitamin E levels. Interestingly, lower levels of vitamin E were detected in patients over age 40.
Açıklama
Anahtar Kelimeler
Biyokimya ve Moleküler Biyoloji, Endokrinoloji ve Metabolizma, Genel ve Dahili Tıp, Kadın Hastalıkları ve Doğum, Beslenme ve Diyetetik
Kaynak
Bakırköy Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
5
Sayı
2
