Altered Serum Chitotriosidase Activity and Irisin Level in Obese Children

Basit Öğe Kaydı
dc.contributor.authorDurankus, Ferit
dc.contributor.authorŞenkal, Evrim
dc.contributor.authorDurankuş, Ramazan
dc.contributor.authorSünnetçi, Eda
dc.contributor.authorSayın, Oya
dc.contributor.authorPotas, Nihan
dc.contributor.authorAlbayrak, Yakup
dc.date.accessioned2024-10-29T17:50:36Z
dc.date.available2024-10-29T17:50:36Z
dc.date.issued2021
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractObjective:In this study, we aimed to investigate serum chitotriosidase (ChT) activity and irisin levels in children with obesity and compare them to those of healthy counterparts. Material and Methods: A total of 91 obese and 83 normal-weight children were included in the study. Serum ChT activity and irisin levels of children with obesity were compared to those of normal-weight children. Results: The mean ChT value in the obese group was 1825.332 ± 4804.147 nmol/L/h and was significantly higher than that in the control group. In contrast, the mean irisin level, 2679.663 ± 5473.58 pg/ml, was lower than that in the control group. The cutoff point of the continuous variable selected in the model for ChT was 601, with 31.9% sensitivity, 90.6% specificity, and an area under the curve of 0.596. The cutoff point for irisin was 901.4, with 83.5% sensitivity, 42.4% specificity, and an area under the curve of 0.617. Conclusion: This study is the first to show decreased serum both serum ChT activity and irisin level and ChT’s association with irisin levels in children with obesity . We argue that ChT and irisin should be considered potential biomarkers of metabolic syndrome in children with obesity.
dc.identifier.doi10.31832/smj.882608
dc.identifier.endpage532
dc.identifier.issn2146-409X
dc.identifier.issue3en_US
dc.identifier.startpage523
dc.identifier.trdizinid1160587
dc.identifier.urihttps://doi.org/10.31832/smj.882608
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1160587
dc.identifier.urihttps://hdl.handle.net/20.500.11776/13081
dc.identifier.volume11
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofSakarya Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectObesity
dc.subjectChildhood
dc.subjectBiomarker
dc.subjectİrisin
dc.subjectChitotriosidase
dc.titleAltered Serum Chitotriosidase Activity and Irisin Level in Obese Children
dc.typeArticle

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu