Inflammatory Mediators Across the Spectrum of Ankle-Brachial Index

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dc.authorscopusid55317577700
dc.authorscopusid10139012600
dc.authorscopusid23968920100
dc.authorscopusid16315021800
dc.authorscopusid14008084500
dc.authorscopusid6505680586
dc.authorscopusid57208165572
dc.authorwosidGurkan, Selami/AAA-9006-2022
dc.authorwosidgur, ozcan/AAA-8847-2022
dc.authorwosidKoc, Filiz/A-9125-2017
dc.contributor.authorÖzkaramanlı Gür, Demet
dc.contributor.authorGür, Özcan
dc.contributor.authorGüzel, Savaş
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorGürkan, Selami
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorKoç, Fatma
dc.date.accessioned2022-05-11T14:10:12Z
dc.date.available2022-05-11T14:10:12Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractAim: Peripheral artery disease (PAD) is a manifestation of atherosclerosis with poor prognosis. It is generally complicated by vascular calcification, which is located either in the intima as patchy infiltrates; or circumferentially in the media, also known as medial arterial calcification (MAC). Obstructive PAD is reflected by low ankle-brachial index (ABI <= 0.9), whereas MAC is revealed by high ABI (ABI > 1.4). Considering the increase in cardiovascular mortality at both ends of the ABI spectrum, this study aimed to explore the underlying pathology through cytokines with established prognostic significance; namely pentraxin-3(PTX3), high sensitivity C-reactive protein (hsCRP), copeptin, soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), NT-proBNP, and neopterin. Methods: We categorized 180 patients with previous multivessel coronary artery bypass grafting surgery into three groups based on their ABI measurements; 60 patients with ABI <= 0.9, 60 patients with ABI within 0.91 and 1.4 (normal ABI), and 60 patients with ABI >1.4 constituted the PAD, normal, MAC groups, respectively. The circulating levels of the biochemical markers were determined. Results: In the PAD group, the cytokine levels with predominantly proatherogenic actions such as PTX3, hsCRP, copeptin, and sTREM-1 were increased and these cytokine levels declined as the ABI increased. In the MAC group, the cytokine concentrations with pleiotropic actions such as NT-proBNP and neopterin increased and; NT-proBNP and neopterin concentrations decreased as ABI decreased. The linear regression analysis revealed that neopterin (beta = 0.72), PTX3 (beta = -0.32), and copeptin (beta = -0.48) were independent predictors of ABI. Conclusions: These findings suggest that different inflammatory pathways influence the pathology at the opposing ends of the ABI spectrum. Consequently, we suggest that PTX3, copeptin, and neopterin are promising biomarkers for future research.
dc.description.sponsorshipScientific Research Projects of Namik Kemal University [NKUBAP.02, 16.043]
dc.description.sponsorshipThis study was funded by the Scientific Research Projects of Namik Kemal University (NKUBAP.02.GA.16.043).
dc.identifier.doi10.5551/jat.44891
dc.identifier.endpage361
dc.identifier.issn1340-3478
dc.identifier.issn1880-3873
dc.identifier.issue4en_US
dc.identifier.pmid30249941
dc.identifier.scopus2-s2.0-85064001402
dc.identifier.scopusqualityQ1
dc.identifier.startpage351
dc.identifier.urihttps://doi.org/10.5551/jat.44891
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5323
dc.identifier.volume26
dc.identifier.wosWOS:000462934300005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzkaramanlı Gür, Demet
dc.institutionauthorGür, Özcan
dc.institutionauthorGüzel, Savaş
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorGürkan, Selami
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorKoç, Fatma
dc.language.isoen
dc.publisherJapan Atherosclerosis Soc
dc.relation.ispartofJournal of Atherosclerosis and Thrombosis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPeripheral artery disease
dc.subjectAnkle-brachial index
dc.subjectPentraxin-3
dc.subjectCopeptin
dc.subjectNeopterin
dc.subjectPeripheral Arterial-Disease
dc.subjectNatriuretic Peptide Levels
dc.subjectVascular Calcification
dc.subjectCardiovascular-Disease
dc.subjectNeopterin
dc.subjectCoronary
dc.subjectAssociation
dc.subjectPrevalence
dc.subjectPlaques
dc.subjectMarker
dc.titleInflammatory Mediators Across the Spectrum of Ankle-Brachial Index
dc.typeArticle

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