The effects of quercetin on liver regeneration after liver resection in rats

Basit Öğe Kaydı
dc.authorid0000-0002-1901-5603
dc.authorscopusid7006356462
dc.authorscopusid35546017100
dc.authorscopusid36023238400
dc.authorscopusid6603961159
dc.authorscopusid14520105500
dc.authorscopusid55987915300
dc.authorwosidKöstek, Osman/AAA-3604-2019
dc.contributor.authorKanter, Mehmet
dc.contributor.authorTuncer, I.
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorAtanassova, P.
dc.contributor.authorTakir, M.
dc.contributor.authorKöstek, O.
dc.date.accessioned2022-05-11T14:42:04Z
dc.date.available2022-05-11T14:42:04Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThe aim of the present study was to assess the influence of quercetine (QE) on liver regeneration after partial hepatectomy (PH) in rats. A total of 24 male Wistar albino rats were divided into three groups: sham-operated (SH), PH and PH+QE; each group contain 8 animals. The rats in QE-treated groups were given QE (15 mg/kg body weight) once a day i. p., for 7 days starting 3 days prior to hepatectomy operation. At 7 days after resection, liver samples were collected. The malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH) levels were estimated in liver homogenates. Moreover, histopathological examination, mitotic index (MI), proliferating cell nuclear antigen labelling, proliferation index (PI), transferase-mediated dUTP nick end-labelling assay, apoptotic index (AI) were evaluated at 7 days after hepatectomy. As a result, QE significantly increased MI, PI, and significantly decreased AI in PH rats. Additionally, QE remarkably inhibited the elevation of MDA, restored impaired antioxidant SOD activity and GSH level, and also attenuated hepatic vacuolar degeneration and sinusoidal congestion. These results suggested that QE treatment had a beneficial effect on liver regenerative capacity of the remnant liver tissue after hepatectomy, probably due to its antioxidative, antiapoptotic and proliferative property.
dc.identifier.doi10.5603/FM.a2015.0086
dc.identifier.endpage187
dc.identifier.issn0015-5659
dc.identifier.issn1644-3284
dc.identifier.issue2en_US
dc.identifier.pmid26431047
dc.identifier.scopus2-s2.0-84973293772
dc.identifier.scopusqualityQ3
dc.identifier.startpage179
dc.identifier.urihttps://doi.org/10.5603/FM.a2015.0086
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9198
dc.identifier.volume75
dc.identifier.wosWOS:000378127700006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErboğa, Mustafa
dc.language.isoen
dc.publisherVia Medica
dc.relation.ispartofFolia Morphologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectquercetine
dc.subjectpartial hepatectomy
dc.subjectoxidative stress
dc.subjectimmunohistochemistry
dc.subjectapoptosis
dc.subjectrat
dc.subjectCell Nuclear Antigen
dc.subjectOxidative Stress
dc.subjectLipid-Peroxidation
dc.subjectPartial-Hepatectomy
dc.subjectReactive Oxygen
dc.subjectProliferation
dc.subjectMitochondrial
dc.subjectAntioxidant
dc.subjectApoptosis
dc.subjectNrf2
dc.titleThe effects of quercetin on liver regeneration after liver resection in rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
9198.pdf
Boyut:
2.12 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu