Meme kanseri evrelemesinde tümör çapı yerine tümör hacminin ölçümü daha mı faydalıdır?
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Dosyalar
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmanın amacı tümör hacminin, meme kanserinin evrelemesin- de tümör çapı yerine kullanılıp kullanılamayacağının ve sağkalımla olan iliş- kisinin tespitidir. Yöntem ve gereçler: T1-3,N0-3,M0 meme kanseri tanısıyla ameliyat edilen ve çalışma kriterlerini sağlayabilen 194 olgunun preoperatif tümör boyutla- rı ve postoperatif patolojik evreleme sonuçları retrospektif olarak incelendi. Tümör çap ve genişlikleri için mamografik/ultrasonografik ölçümlerdeki en büyük değerler, derinlikleri için ise ultrasonografik değer esas alınarak hacim hesaplamaları yapıldı. Tümör hacimleri, ?4 cm3, 4.1-14 cm3, 14.1-32 cm3 ve ?32.1cm3 (?23, >23 - ?33, >33 - ?43 ve >43) şeklinde gruplandırıldı. Bulgular: Tümör hacminin, tümörün lenf nodu kategorisi (R=0.45; p<0.0001 vs R=0.23; p=0.001), patolojik evresi (R=0.52; p<0.0001 vs R=0.43; p<0.0001) ve hasta sağkalımı (R= -0.33; p<0.0001 ve R= -0.18; p<0.012) ile tümör çapına kıyasla daha iyi korelasyon gösterdiği ve univariate analiz ve regresyon testlerinde de üstünlük sağladığı belirlendi. Sonuç: Sınırlı sayıda hastada gerçekleştirdiğimiz çalışmamıza göre, patolo- jik evre, lenf nodu evresi ve sağkalım ile daha iyi korelasyonlar gösteren tü- mör hacminin, standart klinik evreleme parametresi olan tümör çapının ye- rine kullanılabileceği düşünülmüş, konunun netlik kazanabilmesi için geniş hasta serili çalışmalara ihtiyaç olduğu kanısına varılmıştır.
Purpose: The aim of the present study is to determine whether or not tumor volume can be used instead of tumor diameter in breast cancer staging and the relation between tumor volume and survival. Patients and method: The preoperative tumor sizes and the results of post- operative pathological staging of 194 patients who underwent surgery with the diagnosis of T1-3,N0-3,M0 breast cancer and also fulfilled the study cri- teria were retrospectively evaluated. The tumor volume was estimated by using the tumor diameter and the width which were specified according to the highest value at the mammographic and ultrasonographic examinations and using the tumor depth which was designated according to the ultrasono- graphic measurement. The tumor volumes were categorized as, &#8804;4cm3, 4.1- 14 cm3, 14.1-32 cm3 ve &#8805;32.1 cm3 . (&#8804;23, >23 - &#8804;33, >33 - &#8804;43 ve >43). Results: The tumor volume had better correlation than the tumor diam- eter with the classification of lymph node, (R=0.45; p<0.0001 vs R=0.23; p=0.001) pathological stage of the tumor (R=0.52; p<0.0001 vs R=0.43; p<0.0001)and patient survival (R= -0.33; p<0.0001 vs R= -0.18; p<0.012). Moreover, it was detected that the tumor volume had superiority in the uni- variant analysis and regression tests. Conclusion: According to the results of our study including limited number of patients, it has been thought that the tumor volume which was of better cor- relation with the lymph node status, pathological stages of the tumor and survival of the patients can be used instead of the tumor diameter which is a standart clinical staging parameter and that trials of broad patient series are required in order to obtain more conclusive outcomes.
Purpose: The aim of the present study is to determine whether or not tumor volume can be used instead of tumor diameter in breast cancer staging and the relation between tumor volume and survival. Patients and method: The preoperative tumor sizes and the results of post- operative pathological staging of 194 patients who underwent surgery with the diagnosis of T1-3,N0-3,M0 breast cancer and also fulfilled the study cri- teria were retrospectively evaluated. The tumor volume was estimated by using the tumor diameter and the width which were specified according to the highest value at the mammographic and ultrasonographic examinations and using the tumor depth which was designated according to the ultrasono- graphic measurement. The tumor volumes were categorized as, &#8804;4cm3, 4.1- 14 cm3, 14.1-32 cm3 ve &#8805;32.1 cm3 . (&#8804;23, >23 - &#8804;33, >33 - &#8804;43 ve >43). Results: The tumor volume had better correlation than the tumor diam- eter with the classification of lymph node, (R=0.45; p<0.0001 vs R=0.23; p=0.001) pathological stage of the tumor (R=0.52; p<0.0001 vs R=0.43; p<0.0001)and patient survival (R= -0.33; p<0.0001 vs R= -0.18; p<0.012). Moreover, it was detected that the tumor volume had superiority in the uni- variant analysis and regression tests. Conclusion: According to the results of our study including limited number of patients, it has been thought that the tumor volume which was of better cor- relation with the lymph node status, pathological stages of the tumor and survival of the patients can be used instead of the tumor diameter which is a standart clinical staging parameter and that trials of broad patient series are required in order to obtain more conclusive outcomes.
Açıklama
Anahtar Kelimeler
Tıbbi Laboratuar Teknolojisi, Onkoloji
Kaynak
Meme Sağlığı Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
8
Sayı
3
