Increased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study

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dc.authorid0000-0002-5770-344X
dc.authorid0000-0002-8892-0439
dc.authorscopusid27967486000
dc.authorscopusid55936583000
dc.authorscopusid37046703200
dc.authorscopusid26432848600
dc.authorscopusid29067508300
dc.authorscopusid34876196800
dc.authorscopusid25633859900
dc.authorwosidBEYAZYUZ, MURAT/ABA-7934-2020
dc.authorwosidAlbayrak, Yakup/ABA-7651-2020
dc.authorwosidHashimoto, Kenji/I-5800-2015
dc.contributor.authorBeyazyüz, Murat
dc.contributor.authorKufeciler, Tarkan
dc.contributor.authorBulut, Leyla
dc.contributor.authorÜnsal, Cüneyt
dc.contributor.authorAlbayrak, Yakup
dc.contributor.authorAkyol, Esra Soydaş
dc.contributor.authorHashimoto, Kenji
dc.date.accessioned2022-05-11T14:41:05Z
dc.date.available2022-05-11T14:41:05Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Schizophrenia is a chronic and debilitating disorder, the etiology of which remains unclear. Apoptosis is a programmed cell death mechanism that might be implicated in neuropsychiatric disorders, including schizophrenia. In this study, we aimed to compare the serum levels of apoptosis among deficit schizophrenia (DS) syndrome patients, nondeficit schizophrenia (NDS) patients, and healthy controls (HCs). Patients and methods: After the inclusion and exclusion criteria were applied, 23 DS patients, 46 NDS patients, and 33 HCs were included in the study. The serum apoptosis levels were measured using a quantitative sandwich enzyme immunoassay with human monoclonal antibodies directed against DNA and histones. Results: There was a significant difference among the three groups in terms of the levels of apoptosis (F-2,F-96 = 16.58; P<0.001). The serum apoptosis levels in the DS and NDS groups were significantly higher than those in the HC group. Furthermore, the serum apoptosis levels in the DS group were significantly higher than the levels in the NDS group. Conclusion: This study suggests that increased levels of apoptosis may be implicated in the pathophysiology of DS syndrome. However, further studies are needed to support the role of apoptosis in DS.
dc.identifier.doi10.2147/NDT.S106993
dc.identifier.endpage1268
dc.identifier.issn1178-2021
dc.identifier.pmid27307738
dc.identifier.scopus2-s2.0-84970005649
dc.identifier.scopusqualityQ2
dc.identifier.startpage1261
dc.identifier.urihttps://doi.org/10.2147/NDT.S106993
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9060
dc.identifier.volume12
dc.identifier.wosWOS:000376249700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBeyazyüz, Murat
dc.institutionauthorÜnsal, Cüneyt
dc.institutionauthorAlbayrak, Yakup
dc.language.isoen
dc.publisherDove Medical Press Ltd
dc.relation.ispartofNeuropsychiatric Disease and Treatment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectapoptosis
dc.subjectetiology
dc.subjectdeficit
dc.subjectpsychosis
dc.subjectNeurotrophic Factor
dc.subjectOxidative Stress
dc.subjectMechanisms
dc.subjectNeurodegeneration
dc.subjectPathophysiology
dc.subjectAntioxidant
dc.subjectExpression
dc.subjectSchedule
dc.subjectCancer
dc.subjectCortex
dc.titleIncreased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study
dc.typeArticle

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