The Protective Effect of Silymarin on Cholestatic Liver Injury

Basit Öğe Kaydı
dc.authorid0000-0001-6758-7289
dc.authorid0000-0003-2006-9198
dc.authorid0000-0003-2716-6222
dc.authorwosidAZİRET, MEHMET/I-5483-2014
dc.authorwosidSözen, Selim/ABA-6337-2020
dc.authorwosidtokgöz, serhat/F-1573-2016
dc.authorwosidCetinkunar, Suleyman/AFP-2813-2022
dc.contributor.authorBilgin, Bülent Çağlar
dc.contributor.authorTokgöz, Serhat
dc.contributor.authorÇetinkunar, Süleyman
dc.contributor.authorAziret, Mehmet
dc.contributor.authorErdem, Hasan
dc.contributor.authorAktimur, Recep
dc.contributor.authorSözen, Selim
dc.date.accessioned2022-05-11T14:34:56Z
dc.date.available2022-05-11T14:34:56Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractIntroduction: Medical and surgical problems caused by obstructive jaundice is an important problem for surgeons and gastroenterologists. Silymarin prevents liver damage by maintaining the integrity of the plasma membrane. Purpose: The aim of this study was to evaluate whether silymarin administration would protect against cholestatic liver injury in rats with bile duct ligation. Methods: Thirty male Sprague-Dawley rats with a weight of 200-240 g were used in the study. They were randomly divided into three groups (n = 10 for each group): sham group only operated (Group I), control group was bile duct ligation (BDL) (Group II), and treatment group was IR+ BDL+silymarin (Group III) Silymarin 200 mg/kg/day was given by orally to the Silymarin group for 10 days. After 10 days, all rats were sacrificed, plasma and liver samples were obtained. Blood parameters were measured and tissue level of Glutathione (GSH), malondialdehyde (MDA) and copper/zinc superoxide dismutase (Cu / Zn SOD) were determined. The degree of portal inflammation, necrosis, vacuolar degeneration, sinusoidal dilatation, vascular congestion and fibrosis were evaluated histopathologically. Results: In the silymarin treated rats, MDA levels and liver tissue Cu-Zn SOD levels were significantly lower, while GSH levels were significantly higher than that of the BDL group (p = 0.001, p = 0.05, p = 0.001, respectively). In the BDL+silymarin group, the levels of LDH were significantly lower than that of the BDL group (p = 0.01). Conclusions: Our results supported indicate that silymarin exerts a protective and therapeutic effect on cholestatic liver injury in bile duct ligated rats.
dc.identifier.endpage959
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84945178578
dc.identifier.scopusqualityN/A
dc.identifier.startpage953
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8148
dc.identifier.volume31
dc.identifier.wosWOS:000372137700004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSözen, Selim
dc.language.isoen
dc.publisherCarbone Editore
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCholestasis
dc.subjectliver injury
dc.subjectsilymarin
dc.subjectInduced Oxidative Stress
dc.subjectDuct-Ligated Rats
dc.subjectObstructive-Jaundice
dc.subjectHemodynamic Characterization
dc.subjectIschemia-Reperfusion
dc.subjectGlutathione
dc.subjectMelatonin
dc.subjectKetamine
dc.subjectReality
dc.subjectDefense
dc.titleThe Protective Effect of Silymarin on Cholestatic Liver Injury
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
8148.pdf
Boyut:
2.43 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu