Decrease of theta response in euthymic bipolar patients during an oddball paradigm

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dc.authorid0000-0002-0860-0524
dc.authorid0000-0003-0150-5476
dc.authorid0000-0002-8514-0576
dc.authorid0000-0002-8514-0576
dc.authorscopusid54792689200
dc.authorscopusid15044484600
dc.authorscopusid6602570797
dc.authorscopusid35171769200
dc.authorscopusid7006439763
dc.authorwosidGüntekin, Bahar/A-4974-2018
dc.authorwosidTülay, Emine Elif/AAW-1048-2020
dc.authorwosidAtagün, Murat İlhan/ABA-6588-2021
dc.authorwosidAtagun, Murat Ilhan/A-6386-2018
dc.contributor.authorAtagün, Murat İlhan
dc.contributor.authorGuntekin, B.
dc.contributor.authorÖzerdem, A.
dc.contributor.authorTulay, E.
dc.contributor.authorBaşar, E.
dc.date.accessioned2022-05-11T14:41:03Z
dc.date.available2022-05-11T14:41:03Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractTheta oscillations are related to cognitive functions and reflect functional integration of frontal and medial temporal structures into coherent neurocognitive networks. This study assessed event-related theta oscillations in medication-free, euthymic patients with bipolar disorder upon auditory oddball paradigm. Twenty-two DSM-IV euthymic bipolar I (n = 19) and II (n = 3) patients and twenty-two healthy subjects were included. Patients were euthymic for at least 6 months, and psychotropic-free for at least 2 weeks. EEG was recorded at 30 electrode sites. Auditory oddball paradigm and sensory stimuli were used. Event-related Oscillations were analyzed using adaptive filtering in two different theta frequency bands (4-6 Hz, 6-8 Hz). In healthy subjects, slow theta (4-6 Hz) responses were significantly higher than those of euthymic patients upon target, non-target and sensory stimuli (p < 0.05). Fast theta (6-8 Hz) responses of healthy subjects were significantly higher than those of euthymic patients upon target-only stimuli (p < 0.05). Reduced theta oscillations during auditory processing provide strong quantitative evidence of activation deficits in related networks in bipolar disorder. Fast theta responses are related to cognitive functions, whereas slow theta responses are related to sensory processes more than cognitive processes.
dc.identifier.doi10.1007/s11571-012-9228-7
dc.identifier.endpage223
dc.identifier.issn1871-4080
dc.identifier.issn1871-4099
dc.identifier.issue3en_US
dc.identifier.pmid24427202
dc.identifier.scopus2-s2.0-84878114074
dc.identifier.scopusqualityQ3
dc.identifier.startpage213
dc.identifier.urihttps://doi.org/10.1007/s11571-012-9228-7
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9042
dc.identifier.volume7
dc.identifier.wosWOS:000319008800003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAtagün, Murat İlhan
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofCognitive Neurodynamics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBipolar disorder
dc.subjectEvent related oscillations
dc.subjectOddball
dc.subjectTheta
dc.subjectTheta oscillations
dc.subjectMedication-free
dc.subjectEuthymia
dc.subjectCognitive dysfunction
dc.subjectEvent-Related Potentials
dc.subjectFrontal-Midline Theta
dc.subjectWorking-Memory
dc.subjectAffective-Disorder
dc.subjectUnaffected Relatives
dc.subjectBrain Oscillations
dc.subjectEpisodic Retrieval
dc.subjectAuditory P300
dc.subjectRating-Scale
dc.subjectUpper Alpha
dc.titleDecrease of theta response in euthymic bipolar patients during an oddball paradigm
dc.typeArticle

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