Enthesitis may be one of the signs of severe disease in familial Mediterranean fever

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dc.authorid0000-0002-1753-4936
dc.authorid0000-0003-0966-0075
dc.authorid0000-0003-1537-2192
dc.authorscopusid15127959300
dc.authorscopusid57218935872
dc.authorscopusid56086888000
dc.authorscopusid55892516600
dc.authorscopusid55989468100
dc.authorscopusid57218934861
dc.authorscopusid15053582500
dc.authorwosidTezcan, Mehmet Engin/I-4281-2018
dc.authorwosidşen, nesrin/ABI-6368-2020
dc.authorwosidmercan, ridvan/W-3342-2017
dc.contributor.authorŞen, Nesrin
dc.contributor.authorYılmaz, Mesut
dc.contributor.authorMercan, Rıdvan
dc.contributor.authorVolkan, Ömür
dc.contributor.authorYılmaz Öner, Sibel
dc.contributor.authorTükel, Ezgi
dc.contributor.authorTezcan, Mehmet Engin
dc.date.accessioned2022-05-11T14:40:01Z
dc.date.available2022-05-11T14:40:01Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective Familial Mediterranean fever (FMF) is an auto-inflammatory disease that is also characterized with some of the common musculoskeletal features of spondyloarthritis (SpA). Enthesitis is the hallmark of SpA. Recently, it was postulated that exertional leg pain is a possible sign of lower extremity enthesitis associated with FMF severity. In this study, we have evaluated the association between the enthesitis, enthesitis score and disease severity in FMF patients. Methods We enrolled 238 FMF patients that fulfilled the modified Tel-Hashomer criteria. We assessed the presence of enthesitis at the Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) defined sites with standard palpation method. Then, FMF patients dichotomised two groups as enthesitis group and controls. Herein, we evaluated the enthesis extensity with MASES. FMF disease severity was determined via the international severity scoring system for FMF (ISSF). Firstly, we have compared demographic properties, disease-related features and ISSF scores of the groups. Then, we have correlated ISSF with MASES in enthesitis group. Results We showed that 54 (22.6%) of 238 patients had enthesitis. The demographic features were similar between the groups. The enthesitis group had higher ISSF scores (p < 0.001); higher frequency of fever (p = 0.004), exertional leg pain (p < 0.001), myalgia (p < 0.001) and arthritis (p = 0.01); and more intense, widespread, frequent and longer attacks compared with controls. Moreover, there was a weak correlation between ISSF and MASES in the patients with enthesitis. Conclusion Enthesitis may be a sign of more severe FMF phenotype and frequently associated with other musculoskeletal manifestations resemble SpA.
dc.identifier.doi10.1007/s10067-020-05392-x
dc.identifier.endpage1485
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue4en_US
dc.identifier.pmid32920724
dc.identifier.scopus2-s2.0-85090861062
dc.identifier.scopusqualityQ2
dc.identifier.startpage1479
dc.identifier.urihttps://doi.org/10.1007/s10067-020-05392-x
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8833
dc.identifier.volume40
dc.identifier.wosWOS:000569040700002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMercan, Rıdvan
dc.language.isoen
dc.publisherSpringer London Ltd
dc.relation.ispartofClinical Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEnthesitis
dc.subjectFamilial Mediterranean fever
dc.subjectSpondyloarthropathy
dc.subjectEnthesopathy
dc.subjectClassification
dc.subjectCriteria
dc.titleEnthesitis may be one of the signs of severe disease in familial Mediterranean fever
dc.typeArticle

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