Association of vaspin rs2236242 gene variants and circulating serum vaspin concentrations with coronary artery disease in a Turkish population

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dc.authorid0000-0003-4720-1945
dc.authorscopusid35764299300
dc.authorscopusid23391660500
dc.authorscopusid56895970700
dc.authorscopusid57000520600
dc.authorscopusid10139012600
dc.authorscopusid14008084500
dc.authorscopusid56688504600
dc.authorwosidgur, ozcan/AAA-8847-2022
dc.authorwosidGurkan, Selami/AAA-9006-2022
dc.contributor.authorAkçılar, Raziye
dc.contributor.authorYümün, Gündüz
dc.contributor.authorBayat, Zeynep
dc.contributor.authorDonbaloğlu, Mehmet Okan
dc.contributor.authorGür, Özcan
dc.contributor.authorGürkan, Selami
dc.contributor.authorArık, Özlem
dc.date.accessioned2022-05-11T14:36:01Z
dc.date.available2022-05-11T14:36:01Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.description.abstractCoronary artery disease (CAD) is the primary cause of death worldwide. Vaspin was a recently described adipokine, playing a protective role in many metabolic and cardiovascular diseases. This study aimed to assess the relation of serum vaspin levels and vaspin rs2236242 polymorphisms with CAD. The study included 105 healthy subjects and 105 CAD patients. Serum vaspin concentrations and vaspin rs2236242 polymorphisms were determined by enzyme-linked immunosorbent assay and polymerase chain reaction, respectively. There was a statistically significant difference between the genotypes of CAD patients (TT 26.7%, TA 71.4%, and AA 1.9%) and controls (TT 70.5%, TA 28.6%, and AA 1%;chi(2) = 40.3;df = 2;p = .000). The TA genotype increased the risk of CAD (odds ratio [OR] = 6.60; 95% confidence interval [CI] = 3.60-12.1;p = .000) as compared to the TT genotype. There was a statistically significant difference between the allelic distribution of CAD patients (T 62.4% and A 37.6%) and controls (T 84.8% and A 15.2%;chi(2) = 27.0;df = 1;p = .000). Those carrying the A allele had a higher risk of CAD compared to those with the T allele (OR = 3.35; 95% CI = 2.10-5.36;p = .000). The serum vaspin concentrations of the patients with TT, TA, and AA genotypes were 30.4 +/- 1.72, 28.4 +/- 2.89, and 36.4 +/- 6.38 pg/ml, respectively, and there was no significant difference between the serum vaspin levels and vaspin genotypes (p = .696). All of the above suggested that the vaspin rs2236242 polymorphism was associated with CAD in the Turkish population.
dc.identifier.doi10.1002/jcp.30112
dc.identifier.endpage3739
dc.identifier.issn0021-9541
dc.identifier.issn1097-4652
dc.identifier.issue5en_US
dc.identifier.pmid33078402
dc.identifier.scopus2-s2.0-85092690550
dc.identifier.scopusqualityQ1
dc.identifier.startpage3734
dc.identifier.urihttps://doi.org/10.1002/jcp.30112
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8338
dc.identifier.volume236
dc.identifier.wosWOS:000579560200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYümün, Gündüz
dc.institutionauthorDonbaloğlu, Mehmet Okan
dc.institutionauthorGür, Özcan
dc.institutionauthorGürkan, Selami
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Cellular Physiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcoronary artery disease
dc.subjectpolymorphism
dc.subjectvaspin
dc.subjectMetabolic Syndrome
dc.subjectAtherosclerosis
dc.subjectRisk
dc.subjectPolymorphisms
dc.titleAssociation of vaspin rs2236242 gene variants and circulating serum vaspin concentrations with coronary artery disease in a Turkish population
dc.typeArticle

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