The frequency of Cushing's disease, ACTH-independent Cushing's syndrome and autonomous cortisol secretion among Turkish patients with obesity

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dc.authorid0000-0002-0920-6895
dc.authorwosidElbuken, Gulsah/ABD-5689-2020
dc.contributor.authorAtar, Resit Volkan
dc.contributor.authorYıldız, İsmail
dc.contributor.authorTopçu, Birol
dc.contributor.authorElbüken, Gülşah
dc.contributor.authorZuhur, Sayid Shafi
dc.date.accessioned2022-05-11T14:14:00Z
dc.date.available2022-05-11T14:14:00Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractOBJECTIVE: The frequency of Cushing's disease (CD), ACTH-independent Cushing's syndrome (CS) and autonomous cortisol secretion (ACS) in patients with obesity is not well known. Therefore, in the present study, we aimed to assess the frequency of CD, CS and ACS among the patients with obesity. METHODS: This study included 813 patients (683 female, mean age 46.47 +/- 14.23 yr; mean body mass index (BMI) 37.31 +/- 6.50 kg/m(2)). Patients with obesity were classified further to stages 1, 2, and 3, according to BMI. All patients underwent a low dose dexamethasone suppression test (LDDST). The patients with CD, CS, and ACS and patients with simple obesity were compared concerning gender, age, type-2 diabetes, hypertension (HT) and hyperlipidemia (HL). RESULTS: Forty-four (5.4%) out of 813 patients were diagnosed as CD, CS or ACS. CD, CS, and ACS were diagnosed in four (0.4%), two (0.2%), and 33 (4%) patients, respectively. When patients with CD, CS and ACS were compared to the patients with simple obesity, older age at diagnosis, the presence of stage-1 obesity, the presence of HT, and uncontrolled type-2 diabetes were more frequent in patients with CD, CS and ACS (p=0.001, p=0.007, p=0.004, and p=0.0026, respectively). CONCLUSION: The frequency of CD, CS, and ACS is high among patients with obesity. Screening for CD, CS, and ACS in patients with stage-I obesity who are older than 50 years of age with uncontrolled type-2 diabetes and HT may be a reasonable approach.
dc.identifier.doi10.14744/nci.2019.54771
dc.identifier.endpage221
dc.identifier.issn2148-4902
dc.identifier.issue3en_US
dc.identifier.pmid32478291
dc.identifier.startpage214
dc.identifier.urihttps://doi.org/10.14744/nci.2019.54771
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5735
dc.identifier.volume7
dc.identifier.wosWOS:000534635600003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorAtar, Resit Volkan
dc.institutionauthorYıldız, İsmail
dc.institutionauthorTopçu, Birol
dc.institutionauthorElbüken, Gülşah
dc.institutionauthorZuhur, Sayid Shafi
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofNorthern Clinics of Istanbul
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAutonomous cortisol secretion
dc.subjectCushing's syndrome
dc.subjectobesity
dc.subjectSubclinical Hypercortisolism
dc.subjectPrevalence
dc.subjectDiagnosis
dc.subjectSociety
dc.titleThe frequency of Cushing's disease, ACTH-independent Cushing's syndrome and autonomous cortisol secretion among Turkish patients with obesity
dc.title.alternativeThe frequency of Cushing's disease, ACTH-independent Cushing's syndrome and autonomous cortisol secretion among Turkish patients with obesity
dc.typeArticle

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