Comparison of colistin monotherapy and non-colistin combinations in the treatment of multi-drug resistant Acinetobacter spp. bloodstream infections: A Multicenter retrospective analysis

Basit Öğe Kaydı
dc.authorid0000-0002-7149-2968
dc.authorid0000-0002-1104-8232
dc.authorid0000-0002-8977-5931
dc.authorid0000-0002-0244-4006
dc.authorid0000-0003-1514-1685
dc.authorid0000-0003-0502-432X
dc.authorid0000-0002-4034-9202
dc.authorscopusid57211248494
dc.authorscopusid6505508467
dc.authorscopusid23060531400
dc.authorscopusid56029680900
dc.authorscopusid7004827493
dc.authorscopusid23494580100
dc.authorscopusid8726721500
dc.authorwosidARSLAN, FERHAT/ABG-5757-2021
dc.authorwosidOztoprak, Nefise/AAD-2679-2019
dc.authorwosidHatipoğlu, Çiğdem Ataman/AAA-4135-2021
dc.authorwosidaltay, fatma aybala/AFP-3599-2022
dc.authorwosidbalkan, ilker inanc/AAI-1578-2019
dc.authorwosidÖrmen, Bahar/ABA-1027-2021
dc.authorwosidKilic, Aysegul Ulu/AAM-1069-2021
dc.contributor.authorBalkan, İlker İnanç
dc.contributor.authorBatırel, Ayşe
dc.contributor.authorKarabay, Oğuz
dc.contributor.authorAğalar, Canan
dc.contributor.authorAkalın, Şerife
dc.contributor.authorAlici, Özlem
dc.contributor.authorYılmaz, Hava
dc.contributor.authorDoğan, Mustafa
dc.date.accessioned2022-05-11T14:37:23Z
dc.date.available2022-05-11T14:37:23Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.description.abstractObjectives: To compare the efficacy of colistin (COL) monotherapy versus non-COL based combinations in the treatment of bloodstream infections (BSIs) due to multidrug resistant Acinetobacter spp.(MDR-A) . Materials and Methods: Retrospective data of 107 MDR-A BSI cases from 27 tertiary centers in Turkey were included. Primary End-Point: 14-day mortality. Secondary End-Points: Microbial eradication and clinical improvement. Results: Thirty-six patients in the COL monotherapy (CM) group and 71 in the non-COL based combinations (NCC) group were included in the study. Mean age was 59.98 20 years (range: 18-89) and 50.5% were male. Median duration of follow-up was 40 days (range: 9-297). The 14-day survival rates were 52.8% in CM and 47.23% in NCC group (P = 0.36). Microbiological eradication was achieved in 69% of CM and 83% of NCC group (P = 0.13). Treatment failure was detected in 22.9% of cases in both CM and NCC groups. Univariate analysis revealed that mean age (P = 0.001), Charlson comorbidity index (P = 0.03), duration of hospital stay before MDR-A BSI (P = 0.04), Pitt bacteremia score (P = 0.043) and Acute Physiology and Chronic Health Evaluation II score (P = 0.05) were significant in terms of 14-day mortality. Advanced age (P = 0.01) and duration of hospital stay before MDR-A BSI (P = 0.04) were independently associated with 14-day mortality in multivariate analysis. Conclusion: No significant difference was detected between CM and non-COL based combinations in the treatment of MDR-A BSIs in terms of efficacy and 14-day mortality.
dc.identifier.doi10.4103/0253-7613.150383
dc.identifier.endpage100
dc.identifier.issn0253-7613
dc.identifier.issn1998-3751
dc.identifier.issue1en_US
dc.identifier.pmid25821319
dc.identifier.scopus2-s2.0-84923055629
dc.identifier.scopusqualityQ3
dc.identifier.startpage95
dc.identifier.urihttps://doi.org/10.4103/0253-7613.150383
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8673
dc.identifier.volume47
dc.identifier.wosWOS:000349144300018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDoğan, Mustafa
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofIndian Journal of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBlood stream infection
dc.subjectcolistin
dc.subjectmonotherapy
dc.subjectmulti drug resistant Acinetobacter spp
dc.subjectGram-Negative Bacteria
dc.subjectCritically-Ill Patients
dc.subjectBaumannii Bacteremia
dc.subjectRisk-Factors
dc.subjectAntimicrobial Therapy
dc.subjectMortality
dc.subjectOutcomes
dc.subjectImpact
dc.subjectAppropriate
dc.subjectSulbactam
dc.titleComparison of colistin monotherapy and non-colistin combinations in the treatment of multi-drug resistant Acinetobacter spp. bloodstream infections: A Multicenter retrospective analysis
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
8673.pdf
Boyut:
551.53 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu