Tumor regulation of myeloid-derived suppressor cell proliferation and trafficking

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dc.authorid0000-0002-6328-6056
dc.authorid0000-0002-7792-7459
dc.authorid0000-0002-8711-7820
dc.authorscopusid35175256600
dc.authorscopusid22834263600
dc.authorscopusid6602366586
dc.authorscopusid55173255200
dc.authorscopusid7005192342
dc.authorwosidTalmadge, James/AAF-7242-2020
dc.authorwosidYounos, Ibrahim H/F-9225-2015
dc.authorwosidGulen, Dumrul/A-5955-2017
dc.contributor.authorYounos, İbrahim H.
dc.contributor.authorDafferner, Alicia J.
dc.contributor.authorGülen, Dumrul
dc.contributor.authorBritton, Holly C.
dc.contributor.authorTalmadge, James E.
dc.date.accessioned2022-05-11T14:42:10Z
dc.date.available2022-05-11T14:42:10Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractA stress response can induce myeloid progenitor cell (MPC) proliferation, mobilization, and extramedullary hematopoiesis (EMH) within lymphoid and parenchymal organs. Our studies using in vivo BrdU labeling, Ki-67 IHC staining, and carboxyfluorescein succinimidyl ester (CFSE) adoptive cell transfer revealed that spleens, rather than bone marrow (BM) and peripheral blood (PB), from 4T1 mammary tumor-bearing (TB) mice were the primary site of MPC proliferation. The resultant increase in MPCs was associated with tumor hematopoietic growth factor (GF) transcription, decreased apoptosis, as well as, prolonged survival of splenic MPCs. In naive mice. i.v. injected CFSE-labeled MDSCs (myeloid-derived suppressor cells) initially accumulated in the lungs, while in TB mice, they rapidly sequestered in the spleen. In contrast, a few of the injected MDSCs and leukocytes arrested, proliferated, or accumulated in the marrow, tumor, or PB of TB mice. However, BrdU labeling revealed a significant demargination of proliferating splenic MPCs into the PB. In tumors, despite high GF transcript levels, we found that a high frequency of MDSCs was apoptotic. In summary, tumor growth and cytokines regulate MPC proliferation, trafficking, accumulation, apoptosis, and survival. (C) 2012 Elsevier BM. All rights reserved.
dc.description.sponsorshipNebraska Research Initiative (NRI)
dc.description.sponsorshipThis research was funded by a grant from the Nebraska Research Initiative (NRI), Translation of Biotechnology into the Clinic.
dc.identifier.doi10.1016/j.intimp.2012.05.002
dc.identifier.endpage256
dc.identifier.issn1567-5769
dc.identifier.issn1878-1705
dc.identifier.issue3en_US
dc.identifier.pmid22609473
dc.identifier.scopus2-s2.0-84861422421
dc.identifier.scopusqualityQ1
dc.identifier.startpage245
dc.identifier.urihttps://doi.org/10.1016/j.intimp.2012.05.002
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9261
dc.identifier.volume13
dc.identifier.wosWOS:000306037500004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGülen, Dumrul
dc.institutionauthorTanrıverdi, Yeliz
dc.institutionauthorKaya, Ayşe Demet
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Immunopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMDSC
dc.subjectG-CSE
dc.subjectNOS-2
dc.subjectTrafficking
dc.subjectProliferation
dc.subjectTherapeutic Properties
dc.subjectImmune Suppression
dc.subjectMobilization
dc.subjectExpansion
dc.subjectHeterogeneity
dc.subjectAccumulation
dc.subjectInfiltration
dc.subjectModulation
dc.subjectSunitinib
dc.subjectSubsets
dc.titleTumor regulation of myeloid-derived suppressor cell proliferation and trafficking
dc.typeArticle

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