Role of Sodium Levels on Atrial Fibrillation in Heart Failure: Active Player or a Bystander?

dc.authoridAkyüz, Aydın/0000-0003-3304-4125
dc.authorscopusid16315021800
dc.authorscopusid53663196500
dc.authorscopusid55317577700
dc.authorscopusid57224503376
dc.authorscopusid57226870481
dc.authorscopusid6505680586
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorBaykız, Derya
dc.contributor.authorGür, Demet Özkaramanlı
dc.contributor.authorGökçek, Sümeyra
dc.contributor.authorEfe, Muhammet Mucip
dc.contributor.authorAlpsoy, Şeref
dc.date.accessioned2023-04-20T08:01:12Z
dc.date.available2023-04-20T08:01:12Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractBackground: The coexistence of hyponatremia and atrial fibrillation (AF) increases morbidity and mortality in patients with heart failure (HF). However, it is not established whether hyponatremia is related to AF or not. Objective: Our study aims to seek a potential association of hyponatremia with AF in patients with reduced ejection fraction heart failure (HFrEF). Methods: This observational cross-sectional single-center study included 280 consecutive outpatients diagnosed with HFrEF with 40% or less. Based on sodium concentrations <= 135 mEq/L or higher, the patients were classified into hyponatremia (n=66) and normonatremia (n=214). A p-value <0.05 was considered significant. Results: Mean age was 67.6 +/- 10.5 years, 202 of them (72.2%) were male, mean blood sodium level was 138 +/- 3.6 mEq/L, and mean ejection fraction was 30 +/- 4%. Of those, 195 (69.6%) patients were diagnosed with coronary artery disease. AF was detected in 124 (44.3%) patients. AF rate was higher in patients with hyponatremia compared to those with hyponatremia (n=39 [59.1%] vs. n=85 [39.7%), p= 0.020). In the logistic regression analysis, hyponatremia was not related to AF (OR=1.022, 95% CI=0.785-1.330, p=0.871). Advanced age (OR=1.046, 95% CI=1.016-1.177, p=0.003), presence of CAD (OR=2.058, 95% CI=1.122-3.777, p=0.020), resting heart rate (OR=1.041, 95% CI=1.023-1.060, p<0.001), and left atrium diameter (OR=1.049, 95% CI=1.011-1.616, p=0.002) were found to be predictors of AF. Conclusion: AF was higher in outpatients with HFrEF and hyponatremia. However, there is no association between sodium levels and AF in patients with HFrEF.
dc.identifier.doi10.36660/abc.20210139
dc.identifier.endpage718
dc.identifier.issn0066-782X
dc.identifier.issue4en_US
dc.identifier.pmid35137792
dc.identifier.scopus2-s2.0-85129911173
dc.identifier.scopusqualityQ3
dc.identifier.startpage712
dc.identifier.urihttps://doi.org/10.36660/abc.20210139
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10788
dc.identifier.volume118
dc.identifier.wosWOS:000813888900010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorBaykız Derya
dc.institutionauthorGökçek, Sümeyra
dc.institutionauthorEfe, Muhammet Mucip
dc.institutionauthorAlpsoy, Şeref
dc.language.isopt
dc.publisherArquivos Brasileiros Cardiologia
dc.relation.ispartofArquivos Brasileiros De Cardiologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHyponatremia
dc.subjectAtrial Fibrillation
dc.subjectHeart Failure
dc.subjectHyponatremia
dc.subjectResponses
dc.titleRole of Sodium Levels on Atrial Fibrillation in Heart Failure: Active Player or a Bystander?
dc.typeArticle

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