Effects of sodium arsenite on the some laboratory signs and therapeutic role of thymoquinone in the rats

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dc.authorid0000-0003-4819-9963
dc.authorscopusid7003630321
dc.authorscopusid16042227300
dc.authorscopusid56870958100
dc.authorscopusid55916639700
dc.authorscopusid55515412500
dc.authorscopusid56414492000
dc.authorscopusid6701664660
dc.authorwosidAYDIN, BAYRAM OĞUZ/AAL-1136-2020
dc.authorwosidsener, umit/AAZ-7728-2020
dc.contributor.authorAras, S.
dc.contributor.authorGerin, Fethullah
dc.contributor.authorAydın, B.
dc.contributor.authorUstunsoy, S.
dc.contributor.authorŞener, Ümit
dc.contributor.authorTuran, Bünyamin Cüneyt
dc.contributor.authorArmutcu, F.
dc.date.accessioned2022-05-11T14:09:59Z
dc.date.available2022-05-11T14:09:59Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstractOBJECTIVE: Serious health problems in humans are caused by arsenic (As) exposure, which is wide spread in the environment. Sodium arsenite (SAs), capable of inducing macromolecular damage is evaluated for its damaging effect in the blood vessels, liver and kidneys of Wistar rats. This study was undertaken to investigate the ameliorative effects of thymoquinone on SAs-induced oxidative and inflammatory damages in the serum of male Wistar rats. MATERIALS AND METHODS: Wistar Albino rats divided into three groups of nine rats each were administered to controls saline (10 mg/kg), SAs (10 mg/kg), and SAs plus thymoquinone (10 mg/kg/day) for two weeks orally. Biochemical tests were analyzed by a otoanalyzer; nitric oxide levels specthrophometrically, and cytokines were measured by ELISA method in the rat serum samples. RESULTS: Inflammatory cytokines and some biochemical variables were found to be increased in the SAs group compared to control group. On the other hand, thymoquinone supressed these laboratory signs, which are thought to be the characteristic signs of SAs toxicity, most probably by its ameliorative effects including anti-inflammatory and antioxidant properties. CONCLUSIONS: From the results obtained, thymoquinone mitigates SAs-induced adverse effects in the serum of rats, which suggest that it may attenuate inflammation implicated in endotelial dysfunction.
dc.identifier.endpage663
dc.identifier.issn1128-3602
dc.identifier.issue4en_US
dc.identifier.pmid25753884
dc.identifier.scopus2-s2.0-84942305620
dc.identifier.scopusqualityQ2
dc.identifier.startpage658
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5239
dc.identifier.volume19
dc.identifier.wosWOS:000351491900023
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGerin, Fethullah
dc.institutionauthorAydın, B.
dc.institutionauthorŞener, Ümit
dc.institutionauthorTuran, Bünyamin Cüneyt
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSodium arsenite
dc.subjectInflammatory cytokines
dc.subjectThymoquinone
dc.subjectOxidative stress
dc.subjectRats
dc.subjectOxidative Stress
dc.subjectDrinking-Water
dc.subjectExposure
dc.subjectToxicity
dc.subjectAtherosclerosis
dc.subjectAttenuation
dc.subjectExpression
dc.subjectExtract
dc.titleEffects of sodium arsenite on the some laboratory signs and therapeutic role of thymoquinone in the rats
dc.typeArticle

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