Procollagen C-proteinase enhancer-1 and renal failure in multiple myeloma

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dc.authoridBayrakçı, Nergiz/0000-0002-5923-953X
dc.authoridCELIKKOL, ALIYE/0000-0002-3799-4470
dc.authorscopusid34869282100
dc.authorscopusid8570900600
dc.authorscopusid14219156500
dc.authorscopusid57448773900
dc.authorscopusid55858591400
dc.authorscopusid57218879837
dc.contributor.authorBayrakçı, Nergiz
dc.contributor.authorÖzkan, Gülsüm
dc.contributor.authorAkpınar, Seval
dc.contributor.authorEdiz, Bartu
dc.contributor.authorYılmaz, Ahsen
dc.contributor.authorÇelikkol, Aliye
dc.date.accessioned2023-04-20T08:01:12Z
dc.date.available2023-04-20T08:01:12Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractBackground Renal involvement is present in approximately 50% of multiple myeloma (MM) cases and is associated with a poor prognosis. Procollagen C-Proteinase Enhancer 1 (PCPE-1) is an extracellular matrix glycoprotein that has been shown to increase collagen production by enhancing the activity of Procollagen C-Proteinase (PCP) involved in collagen fibrillogenesis and contribute to the fibrotic process. This study investigates the relationship between PCPE-1 and renal function in myeloma patients. Methods Eighty-one adults, consisting of 61 patients diagnosed with MM and 20 healthy controls, were included in this cross-sectional study. The MM patients with renal injury (RI) were classified as MM-RI( +) and those with no RI as MM-RI(-). Results The median serum PCPE-1 level was 10.7 (5.0-39.4) ng/mL for the entire study population, 9.9 (5.0-13.6) ng/mL for the control group, 10.0 (6.4-22.5) ng/mL for the MM-RI(-) group, and 11.4 (8.1-39.4) ng/mL for the MM-RI( +) group. The difference between the control group and MM-RI( +) group was statistically significant (p < 0.013). PCPE-1 levels negatively correlated with estimated glomerular filtration rate (eGFR), serum albumin, and hemoglobin levels but positively correlated with serum creatinine and CRP levels in the entire study population. Among MM patients, only serum phosphorus and beta-2-microglobulin (beta 2M) were positively correlated with PCPE-1. PCPE-1 levels was not affected by other parameters in the entire study population and in the MM group. Conclusions Although serum PCPE-1 was higher in the MM-RI( +) group, it was thought to be associated with low GFR reflecting non-specific kidney injury rather than myeloma-related kidney injury.
dc.identifier.doi10.1007/s11255-022-03378-z
dc.identifier.endpage3038
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue11en_US
dc.identifier.pmid36173536
dc.identifier.scopus2-s2.0-85139129362
dc.identifier.scopusqualityQ2
dc.identifier.startpage3033
dc.identifier.urihttps://doi.org/10.1007/s11255-022-03378-z
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10796
dc.identifier.volume54
dc.identifier.wosWOS:000863153100002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBayrakçı, Nergiz
dc.institutionauthorÖzkan, Gülsüm
dc.institutionauthorAkpınar, Seval
dc.institutionauthorEdiz, Bartu
dc.institutionauthorYılmaz, Ahsen
dc.institutionauthorÇelikkol, Aliye
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Urology and Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGlomerular Filtration Rate
dc.subjectKidney Injury
dc.subjectMyeloma Kidney
dc.subjectProcollagen C-Proteinase Enhancer-1
dc.subjectRenal Fibrosis
dc.subjectBone Morphogenetic Protein-1
dc.subjectKidney-Disease
dc.subjectExpression
dc.subjectOutcomes
dc.titleProcollagen C-proteinase enhancer-1 and renal failure in multiple myeloma
dc.typeArticle

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