Evaluation of vaspin and irisin hormones levels in diabetic rats and relationship with diet

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dc.authoridÇELIKKOL, ALIYE/0000-0002-3799-4470
dc.authoridBOZKIR, CIGDEM/0000-0002-1103-6290
dc.authorwosidÇELIKKOL, ALIYE/ABE-2695-2020
dc.contributor.authorTuğgüm, Sergen
dc.contributor.authorBozkır, Çiğdem
dc.contributor.authorAslan, Serkan
dc.contributor.authorYılmaz, Ahsen
dc.contributor.authorÇelikkol, Aliye
dc.date.accessioned2023-04-20T08:04:15Z
dc.date.available2023-04-20T08:04:15Z
dc.date.issued2022
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Beslenme ve Diyetetik Bölümü
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractBACKGROUND: Type-2 diabetes with an increasing prevalence is a public health problem. Irisin and vaspin, which are secreted a majority from adipose tissue, are discovered hormones recently, and their effects on diabetes are studied. OBJECTIVE: This study aims to the effects of diet on these hormones levels in diabetic rats. METHODS: In this study, ten-week-old 18 Wistar-Albino rats were divided into three groups randomly. The diabetic group (n = 6) was fed a high-fat diet (HFD). Other rats were divided into two control groups, one of them (n = 6) was fed a control diet (CD), and the other group (n = 6) was fed HFD. The feeding time for all groups was 4 weeks. Streptozotocin (STZ) was used for diabetes induction in rats. RESULTS: At the end of the four weeks, the body weight of the diabetic group decreased significantly. In the diabetic group compared to the control groups, it was observed that besides high fasting blood glucose (FBG), triglyceride, total cholesterol levels, and insulin resistance (HOMA-IR) scores. Vaspin levels were significantly higher in diabetic rats, while irisin levels were similar between groups. Besides, vaspin level correlation with biochemical parameters such as glucose, triglycerides, total cholesterol, and HOMA-IR score was significant. CONCLUSION: In conclusion, this study showed that besides the evidence that vaspine is a hormone associated with diabetes, diet composition could give an opinion about the type-2 diabetes process by looking at hormone levels.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Tekirda.g Namik Kemal University [NKUBAP.23, YL.20.243]
dc.description.sponsorshipThe authors disclosed receipt of the following financial support for the research and/or publication of this article: This study was funded by the Scientific Research Projects Coordination Unit of Tekirda.g Namik Kemal University (NKUBAP.23.YL.20.243).
dc.identifier.doi10.3233/MNM-211586
dc.identifier.endpage428
dc.identifier.issn1973-798X
dc.identifier.issn1973-7998
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85140847409
dc.identifier.scopusqualityQ3
dc.identifier.startpage419
dc.identifier.urihttps://doi.org/10.3233/MNM-211586
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11052
dc.identifier.volume15
dc.identifier.wosWOS:000856617700011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTuğgüm, Sergen
dc.institutionauthorAslan, Serkan
dc.institutionauthorÇelikkol, Aliye
dc.language.isoen
dc.publisherIos Press
dc.relation.ispartofMediterranean Journal of Nutrition and Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDiabetes
dc.subjectIrisin
dc.subjectVaspin
dc.subjectNutrition
dc.subjectHigh Fat Diet
dc.subjectAdipose-Tissue
dc.subjectSerum Irisin
dc.subjectMellitus
dc.subjectObesity
dc.titleEvaluation of vaspin and irisin hormones levels in diabetic rats and relationship with diet
dc.typeArticle

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