The effect of gender on response to antithyroid drugs and risk of relapse after discontinuation of the antithyroid drugs in patients with Graves' hyperthyroidism: a multicentre study

Basit Öğe Kaydı
dc.authorid0000-0002-0920-6895
dc.authorid0000-0002-8329-140X
dc.authorwosidElbuken, Gulsah/ABD-5689-2020
dc.authorwosidBayraktaroglu, Taner/Y-8182-2019
dc.contributor.authorZuhur, Sayid Shafi
dc.contributor.authorYıldız, İsmail
dc.contributor.authorAltuntaş, Yüksel
dc.contributor.authorBayraktaroğlu, Taner
dc.contributor.authorErol, Selvinaz
dc.contributor.authorŞahin, Serdar
dc.contributor.authorKadıoğlu, Pınar
dc.contributor.authorElbüken, Gülşah
dc.contributor.authorTopçu, Birol
dc.date.accessioned2022-05-11T14:14:00Z
dc.date.available2022-05-11T14:14:00Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractIntroduction: The outcome of medical treatment in patients with Graves' disease (GD) is generally difficult to predict. In this study, we examined the hypothesis that gender may affect the outcome of treatment with antithyroid drugs (ATDs). Material and methods: This is a retrospective multicentre study including 717 (514 female and 203 male) patients with the first episode of GD treated for at least 12 months. Patients were classified as relapse, poorly controlled (several episodes of hyperthyroidism followed by euthyroidism and rarely hypothyroidism, occurring after titration of ATDs), and remission. Results: During the mean follow-up time of 26.75 +/- 21.25 months (between 1 and 120 months), 269 (37.5%),176 (24.5%), and 272 (37.9%) patients experienced a relapse, a poorly controlled disease, and remained in remission, respectively. During the follow-up time, 223 (43.4%) of the female and only 49 (24%) of the male patients remained in remission. Relapse and poorly controlled disease (non-remitting GD) were more common in male compared to female patients with GD (hazard ratio 1.26, 95% CI: 1.03-133, p - 0.025). Graves' disease in male patients tended to relapse earlier, and male patients tended to have larger goiter sizes at diagnosis as well. The smoking habit was also significantly inure frequent in males compared to female patients with GD. Conclusion: Male patients with GD have a markedly higher frequency of relapse and poorly controlled disease, as compared to female patients. Larger goiter sizes and higher frequency of smoking may contribute to the higher frequency of relapse and poorly controlled disease in male patients.
dc.identifier.doi10.5603/EP.a2020.0007
dc.identifier.endpage212
dc.identifier.issn0423-104X
dc.identifier.issue3en_US
dc.identifier.pmid32154572
dc.identifier.scopus2-s2.0-85089611142
dc.identifier.scopusqualityQ3
dc.identifier.startpage207
dc.identifier.urihttps://doi.org/10.5603/EP.a2020.0007
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5734
dc.identifier.volume71
dc.identifier.wosWOS:000562953800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorZuhur, Sayid Shafi
dc.institutionauthorYıldız, İsmail
dc.institutionauthorElbüken, Gülşah
dc.institutionauthorTopçu, Birol
dc.language.isoen
dc.publisherVia Medica
dc.relation.ispartofEndokrynologia Polska
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthyperthyroidism
dc.subjectGraves' disease
dc.subjectantithyroid drugs
dc.subjectgender
dc.subjectPredict Relapse
dc.subjectDisease
dc.subjectManagement
dc.subjectTherapy
dc.subjectGuidelines
dc.titleThe effect of gender on response to antithyroid drugs and risk of relapse after discontinuation of the antithyroid drugs in patients with Graves' hyperthyroidism: a multicentre study
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
5734-2.pdf
Boyut:
356.22 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu