Plasma Asymmetrıc Dımethylargınıne (ADMA) and Nıtrıc Oxıde (NO) Levels ın Patıents wıth Chronıc Pansınusıtıs

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dc.authorscopusid56865874000
dc.authorscopusid57225982512
dc.authorscopusid57218879837
dc.authorscopusid57195980397
dc.authorscopusid37058172000
dc.authorscopusid57204395799
dc.contributor.authorBulut, F.
dc.contributor.authorTürksever Tetiker, A.
dc.contributor.authorÇelikkol, Aliye
dc.contributor.authorŞafak, A.S.
dc.contributor.authorTopçu, Birol
dc.contributor.authorBallica, B.
dc.date.accessioned2022-05-11T14:02:51Z
dc.date.available2022-05-11T14:02:51Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractChronic pansinusitis is a mucosal inflammation of the nose and all paranasal sinuses with severe inflammation of the upper airways. Asymmetric dimethylarginine (ADMA) is associated with oxidative stress. In this study, we aimed to examine the plasma levels and importance of ADMA and nitric oxide (NO) in patients with chronic pansinusitis. The study was conducted with a total of 64 patients. The study group included a total of 40 patients with chronic pansinusitis. (18 females, 22 males) (mean age 32.27 ± 10.02). The control group consisted of 24 patients (11 females and 13 males). The mean age of the patients in the control group was 31.35 ± 6.05 years. Nasal endoscopic examinations were performed in patients with a history of chronic pansinusitis and symptoms of chronic pansinusitis. Later, the diagnosis of chronic pansinusitis was confirmed with coronal paranasal sinus Computed tomography scans. Plasma ADMA levels were measured by ELISA method and NO levels were measured by Griess method. Plasma ADMA and NO levels of the patients and healthy volunteers were measured and the mean plasma levels of the two groups were compared. ADMA levels were significantly higher in the group with chronic pansinusitis compared to the control group (1.23 ± 0.41 ?M and 0.28 ± 0.06 ?M, respectively) (p < 0.001), while NO levels were significantly lower in the patient group compared to the control group (7.06 ± 1.07 ?M and 12.25 ± 0.95, ?M, respectively) (p < 0.001). Our results show that the increase in ADMA levels and the decrease in NO levels are associated with chronic pansinusitis. According to these results, increased plasma levels of ADMA in chronic pansinusitis may be useful in clinical use as a sign of increased oxidative stress. © 2021, Association of Otolaryngologists of India.
dc.description.sponsorship2019010
dc.description.sponsorshipThe present study has been supported by Istanbul Rumeli University, through the Scientific Research Project no: 2019010.
dc.identifier.doi10.1007/s12070-021-02720-8
dc.identifier.issn2231-3796
dc.identifier.scopus2-s2.0-85109808106
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1007/s12070-021-02720-8
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4516
dc.identifier.wosWOS:000671758100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÇelikkol, Aliye
dc.institutionauthorTopçu, Birol
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofIndian Journal of Otolaryngology and Head and Neck Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectInflammation
dc.subjectN,N-dimethylarginine
dc.subjectNitric oxide
dc.subjectOxidative stress
dc.subjectParanasal sinuses
dc.titlePlasma Asymmetrıc Dımethylargınıne (ADMA) and Nıtrıc Oxıde (NO) Levels ın Patıents wıth Chronıc Pansınusıtıs
dc.typeArticle

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