The effect of acute topiramate administration on morphine withdrawal syndrome and brain-derived neurotrophic factor in central nervous system

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dc.authoridAYDIN, BANU/0000-0002-3267-8620
dc.authoridYANANLI, Hasan Raci/0000-0003-4649-3632
dc.authoridJAFAROVA DEMIRKAPU, MAHLUGA/0000-0001-8717-4342
dc.contributor.authorOzkula, Songul
dc.contributor.authorDemirkapu, Mahluga Jafarova
dc.contributor.authorYananli, Hasan Raci
dc.contributor.authorAydin, Banu
dc.contributor.authorNacar, Cevdet
dc.contributor.authorCabadak, Hulya
dc.date.accessioned2024-10-29T17:58:34Z
dc.date.available2024-10-29T17:58:34Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractObjectivesNucleus accumbens plays an important role in opioid addiction. Topiramate, increases postsynaptic gamma-aminobutyric acid receptor activity and antagonizes glutamatergic activity. Brain-derived neurotrophic factor (BDNF), which plays a key role in synaptic plasticity, is produced from proBDNF. The aim of this study is to investigate the effects of 100 mu M topiramate applied into the lateral ventricle or nucleus accumbens on naloxone-induced morphine withdrawal and the BDNF/proBDNF ratio in the frontal cortex.MethodsIn the study, 36 adult male Wistar rats weighing 250-350 g were used. Morphine dependence was created with morphine pellets following guide cannula implantations. Withdrawal findings were evaluated in naloxone-induced morphine withdrawal syndrome following topiramate administration, and locomotor activity measurements were performed simultaneously. The brains of sacrificed animals were removed for determination of BDNF/proBDNF ratio.ResultsTopiramate administered by either route significantly suppressed the number of jumps in morphine withdrawal. Topiramate applied into the nucleus accumbens significantly reduced stereotypical behavior in morphine withdrawal, but did not cause any changes in other locomotor activity behaviors. Topiramate applied into the lateral ventricle significantly decreased the BDNF/proBDNF ratio, whereas administered into the nucleus accumbens significantly increased this ratio.ConclusionThe findings of this study indicate that topiramate administered into the lateral ventricle and nucleus accumbens reduces naloxone-induced morphine withdrawal symptoms, stereotypical locomotor activity, and changes the BDNF/proBDNF ratio.
dc.description.sponsorshipMarmara University Scientific Research Council [SAG-C-DRP-200318-0098]
dc.description.sponsorshipThis project was funded by the Marmara University Scientific Research Council (SAG-C-DRP-200318-0098).
dc.identifier.doi10.1080/01616412.2023.2203611
dc.identifier.endpage737
dc.identifier.issn0161-6412
dc.identifier.issn1743-1328
dc.identifier.issue8en_US
dc.identifier.pmid37105528
dc.identifier.scopus2-s2.0-85158845664
dc.identifier.scopusqualityQ2
dc.identifier.startpage730
dc.identifier.urihttps://doi.org/10.1080/01616412.2023.2203611
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14397
dc.identifier.volume45
dc.identifier.wosWOS:000975934600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNeurological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnticonvulsant
dc.subjectmBDNF
dc.subjectnucleus accumbens
dc.subjectopioid
dc.subjectproBDNF
dc.titleThe effect of acute topiramate administration on morphine withdrawal syndrome and brain-derived neurotrophic factor in central nervous system
dc.typeArticle

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