Factors leading to dissemination of cutaneous anthrax: an international ID-IRI study

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dc.authorscopusid57907419900
dc.authorscopusid36599200500
dc.authorscopusid57907617100
dc.authorscopusid6506008185
dc.authorscopusid7005578733
dc.authorscopusid57723177100
dc.authorscopusid23985569400
dc.contributor.authorElbahr, U.S.
dc.contributor.authorTekin, R.
dc.contributor.authorPapi?, M.
dc.contributor.authorPandak, N.
dc.contributor.authorErdem, H.
dc.contributor.authorCan, F.K.
dc.contributor.authorGiammanco, A.
dc.contributor.authorDoğan, Mustafa
dc.date.accessioned2023-04-20T08:05:56Z
dc.date.available2023-04-20T08:05:56Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Although anthrax is a rare zoonotic infection, it still causes significant mortality and morbidity. In this multicenter study, which is the largest anthrax case series ever reported, we aimed to describe the factors leading to dissemination of cutaneous anthrax. Methods: Adult patients with cutaneous anthrax from 16 referral centers were pooled. The study had a retrospective design, and included patients treated between January 1, 1990 and December 1, 2019. Probable, and confirmed cases based upon CDC anthrax 2018 case definition were included in the study. A descriptive statistical analysis was performed for all variables. Results: A total of 141 cutaneous anthrax patients were included. Of these, 105 (74%) patients had probable and 36 (26%) had confirmed diagnosis. Anthrax meningitis and bacteremia occurred in three and six patients, respectively. Sequelae were observed in three patients: cicatricial ectropion followed by ocular anthrax (n = 2) and movement restriction on the left hand after surgical intervention (n = 1). One patient had gastrointestinal anthrax. The parameters related to poor outcome (p < 0.05) were fever, anorexia, hypoxia, malaise/fatigue, cellulitis, fasciitis, lymphadenopathy, leukocytosis, high CRP and creatinine levels, longer duration of antimicrobial therapy, and combined therapy. The last two were seemingly the consequences of dissemination rather than being the reasons. The fatality rate was 1.4%. Conclusions: Rapid identification of anthrax is crucial for prompt and effective treatment. Systemic symptoms, disseminated local infection, and high inflammatory markers should alert the treating physicians for the dissemination of the disease. © 2022 The Authors
dc.identifier.doi10.1016/j.nmni.2022.101028
dc.identifier.issn2052-2975
dc.identifier.pmid36193102
dc.identifier.scopus2-s2.0-85138759566
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.nmni.2022.101028
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11115
dc.identifier.volume48
dc.identifier.wosWOS:000884819700008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDoğan, Mustafa
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofNew Microbes and New Infections
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnthrax
dc.subjectBacteremia
dc.subjectGastrointestinal
dc.subjectMeningitis
dc.subjectMortality
dc.subjectOutcome
dc.titleFactors leading to dissemination of cutaneous anthrax: an international ID-IRI study
dc.typeArticle

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