Effect of Obesity on Endothelial Function and Subclinical Atherosclerosis in Children

Basit Öğe Kaydı
dc.authorid0000-0002-4060-0583
dc.authorid0000-0001-5992-9488
dc.authorscopusid6505680586
dc.authorscopusid16315021800
dc.authorscopusid26532378600
dc.authorscopusid36165893600
dc.authorscopusid37058172000
dc.authorscopusid6601976056
dc.authorwosidDonma, Mustafa Metin/ABF-2169-2021
dc.authorwosidDonma, Metin/AAB-6079-2020
dc.authorwosidDonma, Orkide/AAI-1853-2019
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorAkkoyun, Dursun Çayan
dc.contributor.authorNalbanto?lu, Burçin
dc.contributor.authorTopçu, Birol
dc.contributor.authorDonma, Mustafa Metin
dc.date.accessioned2022-05-11T14:10:08Z
dc.date.available2022-05-11T14:10:08Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractWe aimed to measure flow-mediated dilation (FMD), carotid intima-media thickness (cIMT), and to evaluate the effects of waist circumference (WC), and body mass index Z (BMI-Z) score on these parameters in obese children. This case-control cross-sectional study included 70 obese and 40 non-obese children aged 7-14 years who presented with various complaints and had no concomitant diseases. FMD and cIMT were measured in all subjects and correlated with anthropometric and biochemical factors. WC, BMI-Z score, systolic and diastolic blood pressure (BP), triglyceride (TG) and insulin concentrations, and homeostatic model assessment (HOMA) index were significantly higher, whereas high density lipoprotein (HDL) -cholesterol concentration was significantly lower in the obese than in the non-obese group. FMD values were significantly lower, whereas cIMT values were significantly higher in obese than in non-obese subjects. FMD negatively correlated with WC, BMI-Z score, serum insulin level, HOMA, systolic BP, triglyceride but positively with HDL-cholesterol. cIMT positively correlated with WC, BMI-Z score, serum insulin level, HOMA, systolic BP, triglyceride but negatively with HDL-cholesterol. Increased WC, BMI-Z score, serum insulin level, HOMA, systolic BP, triglyceride and decreased HDL-cholesterol in obese children contribute to endothelial dysfunction and early subclinical atherosclerosis compared to their normal weight peers.
dc.identifier.doi10.15197/sabad.1.11.59
dc.identifier.endpage147
dc.identifier.issn1304-3889
dc.identifier.issn1304-3897
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84908403249
dc.identifier.scopusqualityN/A
dc.identifier.startpage141
dc.identifier.urihttps://doi.org/10.15197/sabad.1.11.59
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5301
dc.identifier.volume11
dc.identifier.wosWOS:000421937800002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorAkkoyun, Dursun Çayan
dc.institutionauthorNalbanto?lu, Burçin
dc.institutionauthorTopçu, Birol
dc.institutionauthorDonma, Mustafa Metin
dc.language.isoen
dc.publisherModestum Ltd
dc.relation.ispartofEuropean Journal of General Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChildren
dc.subjectcarotid intima-media thickness
dc.subjectflow mediated-dilatation
dc.subjectobesity
dc.subjectIntima-Media Thickness
dc.subjectCardiovascular Risk-Factors
dc.subjectAdolescent Overweight
dc.subjectBlood-Pressure
dc.subjectMarkers
dc.subjectImpact
dc.titleEffect of Obesity on Endothelial Function and Subclinical Atherosclerosis in Children
dc.title.alternativeÇocuklarda obezitenin endotel fonksiyonu ve subklinik ateroskleroz üzerine etkisi]
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
5301.pdf
Boyut:
314.98 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu