Relationship of PCNA, C-erbB2 and CD44s expression with tumor grade and stage in urothelial carcinomas of the bladder

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dc.authorid0000-0002-8497-4704
dc.authorid0000-0002-8796-988X
dc.authorscopusid56260632400
dc.authorscopusid6603721364
dc.authorscopusid55945180700
dc.authorscopusid17134802600
dc.authorscopusid55682194900
dc.authorscopusid55755871000
dc.authorscopusid14622668400
dc.authorwosidErkorkmaz, Unal/B-1270-2016
dc.authorwosidYavuz, Alpaslan/H-3947-2014
dc.authorwosidErkorkmaz, Ünal/AAA-4241-2022
dc.contributor.authorYıldırım, Ayhan
dc.contributor.authorKösem, Mustafa
dc.contributor.authorSayar, İlyas
dc.contributor.authorGelincik, İbrahim
dc.contributor.authorYavuz, Alparslan
dc.contributor.authorBozkurt, Aliseydi
dc.contributor.authorBayram, İrfan
dc.date.accessioned2022-05-11T14:36:54Z
dc.date.available2022-05-11T14:36:54Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractIn the present study, the intention was to reveal the relationship of histological grade and stage with c-erbB2, CD44s, and PCNA immunoreactivity in bladder urothelial carcinomas (UC). In our study, we evaluated 46 items of transurethral resection material of patients submitted by YYU Faculty of Medicine, Main Department of Pathology, with a mass revealed in their bladder after clinical and radiological studies at our laboratories and who were diagnosed with urothelial carcinomas. PCNA, c-erbB2, and CD44s were applied in an immunohistochemical manner comprised from nine low-malignant potential papillary urothelial neoplasia, 23 low-grade papillary urothelial carcinoma, and 14 high-grade papillary urothelial carcinoma. Immunostaining was scored according to the percentage of positive cells. The immunohistochemical study demonstrated that the c-erbB2 and PCNA staining ratio increased when an increase occurred in stage and grade. The CD44s staining ratio decreased. C-erbB2, PCNA, and CD44s appear to be a useful marker in the assessment of the prognosis and treatment options in urothelial carcinomas.
dc.identifier.endpage1523
dc.identifier.issn1940-5901
dc.identifier.issue6en_US
dc.identifier.pmid25035774
dc.identifier.scopus2-s2.0-84904036546
dc.identifier.scopusqualityN/A
dc.identifier.startpage1516
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8474
dc.identifier.volume7
dc.identifier.wosWOS:000341255900004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGelincik, İbrahim
dc.language.isoen
dc.publisherE-Century Publishing Corp
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectUrothelial carcinomas
dc.subjectPCNA
dc.subjectCD44
dc.subjectC-erbB2
dc.subjectimmunohistochemical study
dc.subjectTransitional-Cell Carcinoma
dc.subjectUrinary-Bladder
dc.subjectNuclear Antigen
dc.subjectProtein Expression
dc.subjectGene
dc.subjectP53
dc.subjectCytokeratin-20
dc.subjectClassification
dc.subjectRecurrence
dc.subjectPrognosis
dc.titleRelationship of PCNA, C-erbB2 and CD44s expression with tumor grade and stage in urothelial carcinomas of the bladder
dc.typeArticle

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