Protective Effects of Curcumin against Formaldehyde-Induced Renal Toxicity in Rats

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dc.authorscopusid55515412500
dc.authorscopusid26434076100
dc.authorscopusid57216014831
dc.authorscopusid25647609500
dc.authorscopusid17134802600
dc.authorscopusid36866111300
dc.authorscopusid7006831777
dc.contributor.authorŞener, Ümit
dc.contributor.authorUygur, Ramazan
dc.contributor.authorKurt, Ömer
dc.contributor.authorÇağlar, Veli
dc.contributor.authorGelincik, İbrahim
dc.contributor.authorGürel, A.
dc.contributor.authorErdoğan, H.
dc.date.accessioned2022-05-11T14:07:37Z
dc.date.available2022-05-11T14:07:37Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjective: To explore the protective effects of curcumin against renal injury induced by formaldehyde in rats. Methods: A total of 21 male Sprague-Dawley rats were included. The animals were divided into three groups. The control group received 10 ml/kg of physiological saline intragastrically and intraperitoneally on a daily basis. The formaldehyde group were given 10 ml/kg of physiological saline intragastrically plus 10 mg/kg of formaldehyde intraperitoneally. The formaldehyde + curcumin group received 10 mg/kg of intraperitoneal formaldehyde daily as well as 100 mg/kg of curcumin intragastrically. After the completion of 14 days, the kidneys were removed. Tissue microscopic examination was performed with haematoxylin-eosin and periodic acid-Schiff staining. Also, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and xanthine oxidase (XO) activities, and malondialdehyde (MDA) and nitric oxide (NO) levels were measured in tissue samples. Results: Formaldehyde induced renal injury. The degenerative tissue changes in the formaldehyde + curcumin group seemed to regress, exhibiting similar characteristics to those of the controls. MDA, XO and NO were significantly higher in formaldehyde group than in controls, while a significant reduction occurred in SOD, CAT and GSH-Px activities in the formaldehyde group. Also, renal tissue MDA, XO and NO were significantly lower in the formaldehyde + curcumin group than in the formaldehyde group, while tissue SOD, CAT and GSH-Px activities were significantly higher. Conclusion: Curcumin improved the formaldehyde-induced renal degeneration. Also, curcumin was found to prevent the reduction in SOD, CAT and GSH-Px activities, while preventing MDA, XO and NO levels, exhibiting a protective effect against the formaldehyde-induced oxidative renal injury.
dc.identifier.doi10.7727/wimj.2015.385
dc.identifier.endpage344
dc.identifier.issn0043-3144
dc.identifier.issn2309-5830
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85122056023
dc.identifier.scopusqualityQ4
dc.identifier.startpage338
dc.identifier.urihttps://doi.org/10.7727/wimj.2015.385
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5157
dc.identifier.volume69
dc.identifier.wosWOS:000719641000014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorŞener, Ümit
dc.institutionauthorUygur, Ramazan
dc.institutionauthorKurt, Ömer
dc.institutionauthorÇağlar, Veli
dc.institutionauthorGelincik, İbrahim
dc.institutionauthorGürel, A.
dc.institutionauthorErdoğan, H.
dc.language.isoen
dc.publisherUniv West Indies Faculty Medical Sciences
dc.relation.ispartofWest Indian Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCurcumin
dc.subjectformaldehyde
dc.subjectkidney
dc.subjectoxidative stress
dc.subjectrenal toxicity
dc.subjectNitric-Oxide Synthase
dc.subjectOxidative Stress
dc.subjectInflammatory Response
dc.subjectLung Inflammation
dc.subjectBone-Marrow
dc.subjectVitamin-E
dc.subjectNephropathy
dc.subjectLiver
dc.subjectSerum
dc.titleProtective Effects of Curcumin against Formaldehyde-Induced Renal Toxicity in Rats
dc.typeArticle

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