Atherosclerosis, some serum inflammatory markers in psoriasis

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dc.authorid0000-0003-0000-5568
dc.authorscopusid6505680586
dc.authorscopusid16315021800
dc.authorscopusid27867662800
dc.authorscopusid26532378600
dc.authorscopusid37058172000
dc.authorscopusid23968920100
dc.authorscopusid55413116500
dc.authorwosidErfan, Gamze/W-8139-2018
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorAkyuz, A.
dc.contributor.authorErfan, Gamze
dc.contributor.authorAkkoyun, Dursun Çayan
dc.contributor.authorTopçu, Birol
dc.contributor.authorGüzel, Savaş
dc.contributor.authorKulaç, Mustafa
dc.date.accessioned2022-05-11T14:09:56Z
dc.date.available2022-05-11T14:09:56Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractAim. Psoriasis is an autoimmune inflammatory disease which is associated with increased inflammatory markers and atherosclerosis. We wanted to investigate whether there is a relationship between some inflammatory markers and subclinical atherosclerosis markers. Methods. We studied 60 psoriasis patients and 50 healthy controls. Demographic, biochemical parameters, C3, C4, d-dimer, CRP, fibrinogen and YKL-40 (human cartilage glyco-protein-39) levels were measured. After measuring carotid intima-media thickness (cIMT) and aortic elasticity parameters such as aortic strain, (beta) stiffness index and compliance, statistical comparisons were done. Results. Patients with psoriasis had significantly higher diastolic blood pressure, CRP, fibrinogen, C3, uric acid levels, beta-stiffness index, and cIMT values than the control group. cIMT was correlated with CRP, YKL-40 and psoriasis area and severity index (PASI) score (r=0.219, P=0.038; r=0.225, P=0.033 and r=0.275, P=0.034). Aortic strain (%), aortic compliance and aortic stiffness index were correlated with C3 (r=-0.349, r=-0.526 and r=0.235) and fibrinogen (r=-0.354, r=-0.275 and r=0.289), all P values <0.05, but not with PASI score. The presence of psoriasis was related to aortic strain (beta +/- SE: -2.055 +/- 0.861, P=0.019) and beta-stiffness index (beta +/- SE: 2.934 +/- 1.143, P=0.012). Conclusion. Serum C3, CRP, fibrinogen and YKL-40 levels are elevated as well as increased cIMT and impaired aortic elasticity in psoriasis. CRP, YKL-40 and PASI score are correlated with cIMT. Increased serum C3 and fibrinogen levels correlate negatively with aortic strain and aortic compliance, and correlate positively with the beta-stiffness index.
dc.identifier.endpage175
dc.identifier.issn0392-0488
dc.identifier.issn1827-1820
dc.identifier.issue2en_US
dc.identifier.pmid24819636
dc.identifier.scopus2-s2.0-84903178044
dc.identifier.scopusqualityN/A
dc.identifier.startpage167
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5213
dc.identifier.volume149
dc.identifier.wosWOS:000337261100003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorAkyuz, A.
dc.institutionauthorErfan, Gamze
dc.institutionauthorAkkoyun, Dursun Ceyhan
dc.institutionauthorTopçu, Birol
dc.institutionauthorGüzel, Savaş
dc.institutionauthorKulaç, Mustafa
dc.language.isoen
dc.publisherEdizioni Minerva Medica
dc.relation.ispartofGiornale Italiano Di Dermatologia E Venereologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPsoriasis
dc.subjectAtherosclerosis
dc.subjectAutoimmune diseases
dc.subjectIntima-Media Thickness
dc.subjectIncreased Arterial Stiffness
dc.subjectAortic Stiffness
dc.subjectSubclinical Atherosclerosis
dc.subjectCardiovascular Mortality
dc.subjectRisk
dc.subjectDisease
dc.subjectYkl-40
dc.subjectBiomarker
dc.subjectEvents
dc.titleAtherosclerosis, some serum inflammatory markers in psoriasis
dc.typeArticle

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