Changes of cerebellar cortex in a valproic acid-induced rat model of autism

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dc.authoridYUCEL, FERRUH/0000-0002-1238-1483
dc.authorscopusid57224881624
dc.authorscopusid6701409060
dc.contributor.authorAlpay, Meltem
dc.contributor.authorYücel, Ferruh
dc.date.accessioned2023-04-20T08:01:12Z
dc.date.available2023-04-20T08:01:12Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.description.abstractIn this study, 32 male Sprague-Dawley rats (8 for each group) were used in total to examine the effects of valproic acid on rat cerebellum. It was determined that the experimental group received valproic acid (600 mg/kg) on embryonic day 15 and postnatal day 11, whereas the control group was treated with saline on the same days. Moreover, on the postnatal 30th day, the cerebellums of all pups were removed and prepared for light and electron microscopy. The numerical density of granule cells in the cerebellum of experimental groups of rats increased, whereas the numerical density of Purkinje cells decreased. Furthermore, the granule cells had a smaller mean nuclear diameter in one of the experimental groups, while the Purkinje cells had in both experimental groups than those in the comparison group. Thus, the numerical density of synaptic disks and their mean diameter in the cerebellar granular layer of experimental groups were significantly decreased compared to the corresponding controls; also, the synapse-to-neurons ratio, a parameter indicating interneural connectivity, was the same. Consequently, it was seen that valproic acid administration to pups in prenatal or early postnatal days causes changes in number of neurons and synapses in the cerebellum of rats.
dc.description.sponsorshipESOGU-Scientific Research Projects Commission (Eskiehir Osmangazi universitesi) [2782035]
dc.description.sponsorshipThis research has been supported by the ESOGU-Scientific Research Projects Commission (Eskiehir Osmangazi universitesi, Grant No. 2782035).
dc.identifier.doi10.1002/jdn.10213
dc.identifier.issn0736-5748
dc.identifier.issn1873-474X
dc.identifier.pmid35831992
dc.identifier.scopus2-s2.0-85134371142
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/jdn.10213
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10790
dc.identifier.wosWOS:000827921900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlpay, Meltem
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofInternational Journal of Developmental Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAutism Spectrum Disorder
dc.subjectCerebellar Cortex
dc.subjectElectron Microscopy
dc.subjectStereology
dc.subjectValproic Acid (Vpa)
dc.subjectPrenatal Stress
dc.subjectConnectivity
dc.subjectExposure
dc.subjectAmygdala
dc.subjectAnatomy
dc.titleChanges of cerebellar cortex in a valproic acid-induced rat model of autism
dc.typeArticle

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