Effects of experimental diabetes on testis proliferations and apoptosis in rats

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dc.authorscopusid24436194200
dc.authorscopusid7006356462
dc.authorscopusid36023238400
dc.authorscopusid6506497279
dc.contributor.authorAktaş, Cevat
dc.contributor.authorKanter, Mehmet
dc.contributor.authorErbo?a, Mustafa
dc.contributor.authorTimurkan, Hüseyin
dc.date.accessioned2022-05-11T14:41:24Z
dc.date.available2022-05-11T14:41:24Z
dc.date.issued2011
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThis work aimed to investigate the role of diabetes on cell proliferation, and apoptosis in testis. The rats were randomly allotted into one of two experimental groups: control and diabetic group; each group contain 10 animals. Diabetes was induced by a single intraperitoneal injection of STZ (50 mg/kg). Testicular damage was examined by using hematoxylin and eosin, immunohistochemical staining of proliferating cell nuclear antigen (PCNA), and apoptosis was determined by terminal-deoxynucleotidyl-transferase mediated dUTP nick end labeling (TUNEL). Potential disorders associated with seminiferous tubular sperm formation were evaluated using the Johnsen score. The mean seminiferous tubule diameter (MSTD) and mean testicular biopsy score (MTBS) values were significantly decreased in diabetic group was compared to the control group. Our data indicate a significant reduction in the expression of PCNA and an enhancement in the activity of TUNEL in testis tissues of the diabetic group. The effects of diabetes on spermatogenesis can be clearly detected as a testicular cell death and decrease in MTBS, MSTD, and PCNA expression. © 2011 OMU All rights reserved.
dc.identifier.doi10.5835/jecm.omu.28.03.001
dc.identifier.endpage98
dc.identifier.issn1300-2996
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84858830586
dc.identifier.scopusqualityN/A
dc.identifier.startpage94
dc.identifier.urihttps://doi.org/10.5835/jecm.omu.28.03.001
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9173
dc.identifier.volume28
dc.indekslendigikaynakScopus
dc.institutionauthorAktaş, Cevat
dc.language.isoen
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectExperimental diabetes
dc.subjectImmunohistochemistry
dc.subjectPCNA
dc.subjectRat
dc.subjectTestis
dc.subjectTUNEL
dc.titleEffects of experimental diabetes on testis proliferations and apoptosis in rats
dc.typeArticle

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