Serum Fetuin-A Levels in Patients with Bilateral Basal Ganglia Calcification

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dc.contributor.authorDemiryurek, Bekir Enes
dc.contributor.authorGündoğdu, Aslı Aksoy
dc.date.accessioned2022-05-11T14:40:17Z
dc.date.available2022-05-11T14:40:17Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractBackground and Purpose: The idiopathic basal ganglia calcification (Fahr syndrome) may occur due to senility. Fetuin-A is a negative acute phase reactant which inhibits calcium-phosphorus precipitation and vascular calcification. In this study, we aimed to evaluate whether serum fetuin-A levels correlate with bilateral basal ganglia calcification. Method: Forty-five patients who had bilateral basal ganglia calcification on brain CT were selected according to the inclusion and exclusion criteria, and 45 age and gender-matched subjects without basal ganglia calcification were included for the control group. Serum fetuin-A levels were measured from venous blood samples. All participants were divided into two groups; with and without basal ganglia calcification. These groups were divided into subgroups regarding age (18-32 and 33-45 years of age) and gender (male, female). Results: We detected lower levels of serum fetuin-A in patients with basal ganglia calcification compared with the subjects without basal ganglia calcification. In all subgroups (female, male, 18-32 years and 33-45 years), mean fetuin-A levels were significantly lower in patients with basal ganglia calcification (p = 0.017, p = 0.014, p = 0.024, p = 0.026, p = 0.01 respectively). And statistically significantly lower levels of fetuin-A was found to be correlated with the increasing densities of calcification in the calcified basal ganglia group (p-value: < 0.001). Conclusion: Considering the role of fetuin-A in tissue calcification and inflammation, higher serum fetuin-A levels should be measured in patients with basal ganglia calcification. We believe that the measurement of serum fetuin-A may play a role in the prediction of basal ganglia calcification as a biomarker.
dc.identifier.doi10.1016/j.neulet.2017.12.050
dc.identifier.endpage152
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.pmid29288724
dc.identifier.scopus2-s2.0-85039720876
dc.identifier.scopusqualityQ2
dc.identifier.startpage148
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2017.12.050
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8927
dc.identifier.volume666
dc.identifier.wosWOS:000426234700025
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGündoğdu, Aslı Aksoy
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofNeuroscience Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFetuin-A
dc.subjectCalcification
dc.subjectBasal ganglia
dc.subjectMultiple-Sclerosis
dc.subjectAlzheimers-Disease
dc.subjectVascular Calcification
dc.subjectGlycoprotein
dc.subjectAssociation
dc.subjectBiomarkers
dc.subjectGrowth
dc.subjectAhsg
dc.subjectCsf
dc.subjectAntagonist
dc.titleSerum Fetuin-A Levels in Patients with Bilateral Basal Ganglia Calcification
dc.typeArticle

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