Soluble urokinase-type plasminogen activator receptor is a novel biomarker predicting acute exacerbation in COPD

Basit Öğe Kaydı
dc.authorid0000-0002-4910-149X
dc.authorscopusid36664687200
dc.authorscopusid54892706700
dc.authorscopusid37087014000
dc.authorscopusid42561399200
dc.authorscopusid56437691600
dc.authorscopusid50461632900
dc.authorscopusid55414530500
dc.authorwosidÇınarka, Halit/AAK-6830-2021
dc.contributor.authorGümüş, Aziz
dc.contributor.authorAltıntaş, Nejat
dc.contributor.authorCinarka, Halit
dc.contributor.authorKırbaş, Aynur
dc.contributor.authorHaziroglu, Muge
dc.contributor.authorKarataş, Mevlüt
dc.contributor.authorŞahin, Unal
dc.date.accessioned2022-05-11T14:39:47Z
dc.date.available2022-05-11T14:39:47Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory condition, and progresses with acute exacerbations. (AE). During AE, levels of acute phase reactants such as C-reactive protein (CRP) and inflammatory cells in the circulation increase. Soluble urokinase-type plasminogen activator receptor (suPAR) levels increase in acute viral and bacterial infections and in diseases involving chronic inflammation. The purpose of this study was to investigate the effectiveness of suPAR in predicting diagnosis of AE of COPD (AE-COPD) and response to treatment. Methods: The study population consisted of 43 patients diagnosed with AE-COPD and 30 healthy controls. suPAR, CRP, and fibrinogen levels were measured on the first day of hospitalization and on the seventh day of treatment. Results: We found that fibrinogen (P<0.001), CRP (P<0.001), and suPAR (P<0.001) were significantly higher in patients with AE-COPD than in healthy controls. Fibrinogen (P<0.001), CRP (P=0.001), and suPAR (P<0.001) were significantly decreased by the seventh day of treatment. However, the area under receiver operator characteristic curve showed that suPAR is superior to CRP and fibrinogen in distinguishing AE-COPD. There was a correlation between fibrinogen, CRP, and suPAR. However, only fibrinogen was a powerful predictor of suPAR in multiple linear regression. In multiple logistic regression, only suPAR and fibrinogen were strong predictors of AE-COPD (P=0.002 and P=0.014, respectively). Serum suPAR was negatively correlated with forced expiratory volume in 1 second (r=-478, P=0.001). Conclusion: suPAR is a marker of acute inflammation. It is well correlated with such inflammation markers as CRP and fibrinogen. suPAR can be used as a predictor of AE-COPD and in monitoring response to treatment.
dc.identifier.doi10.2147/COPD.S77654
dc.identifier.endpage365
dc.identifier.issn1178-2005
dc.identifier.pmid25709430
dc.identifier.scopus2-s2.0-84923082118
dc.identifier.scopusqualityQ1
dc.identifier.startpage357
dc.identifier.urihttps://doi.org/10.2147/COPD.S77654
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8725
dc.identifier.volume10
dc.identifier.wosWOS:000349372200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAltıntaş, Nejat
dc.language.isoen
dc.publisherDove Medical Press Ltd
dc.relation.ispartofInternational Journal of Chronic Obstructive Pulmonary Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbiomarker
dc.subjectchronic obstructive pulmonary disease
dc.subjectinflammation
dc.subjectsuPAR
dc.subjectObstructive Pulmonary-Disease
dc.subjectC-Reactive Protein
dc.subjectInflammatory Biomarkers
dc.subjectPlasma-Fibrinogen
dc.subjectMortality
dc.subjectLevel
dc.subjectSupar
dc.subjectRisk
dc.titleSoluble urokinase-type plasminogen activator receptor is a novel biomarker predicting acute exacerbation in COPD
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
8725.pdf
Boyut:
1.29 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu