Relationship Among Pulmonary Hypertension, Autoimmunity, Thyroid Hormones and Dyspnea in Patients With Hyperthyroidism

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dc.authorid0000-0002-0920-6895
dc.authorid0000-0001-8084-848X
dc.authorid0000-0002-3053-9133
dc.authorscopusid36656843500
dc.authorscopusid53663196500
dc.authorscopusid57190404723
dc.authorscopusid35949526800
dc.authorscopusid55753696900
dc.authorscopusid35271464000
dc.authorwosidSahin, Ertan/AAG-8999-2020
dc.authorwosidElbuken, Gulsah/ABD-5689-2020
dc.authorwosidZuhur, Sayid/AAC-6839-2020
dc.authorwosidBaykız, Derya/ABD-7865-2020
dc.contributor.authorZuhur, Sayid Shafi
dc.contributor.authorBaykız, Derya
dc.contributor.authorKara, Sonat Pınar
dc.contributor.authorŞahin, Ertan
dc.contributor.authorKuzu, İdris
dc.contributor.authorElbüken, Gülşah
dc.date.accessioned2022-05-11T14:12:51Z
dc.date.available2022-05-11T14:12:51Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nükleer Tıp Ana Bilim Dalı
dc.description.abstractObjective: Previous studies have reported conflicting results regarding the mechanisms underlying the pathophysiology of pulmonary hypertension (PHT) in patients with hyperthyroidism. Therefore, in this study, we investigated the association between PHT and thyroid-stimulating hormone (TSH) receptor antibody, thyroid peroxidase antibody, thyroglobulin antibody, TSH, fT3, fT4 and dyspnea during daily activities in a large population of patients with hyperthyroidism. Methods: A total of 129 consecutive patients with hyperthyroidism, 37 with hypothyroidism and 38 euthyroid controls were enrolled in this study. The modified medical research council scale was used for the assessment of dyspnea in daily activities. All the patients and euthyroid controls underwent transthoracic echocardiography for the assessment of PHT. Results: Mild PHT was present in 35%, 36%, 13.5% and 5% of the patients with Graves' disease, toxic multinodular goiter, hypothyroidism and euthyroid controls, respectively. Pulmonary vascular resistance (PVR) was higher in hyperthyroid patients with PHT than in those without PHT. Moreover, a significant positive correlation was found between modified medical research council scale and pulmonary artery systolic pressure as well as PVR in patients with hyperthyroidism. No association was found between PHT and serum TSH receptor antibody, thyroid peroxidase antibody, thyroglobulin antibody, TSH, fT3 and fT4 levels. Conclusions: Mild PHT is present in a significant proportion of patients with hyperthyroidism, regardless of etiology. PVR appears to be the main cause of PHT in patients with hyperthyroidism, and neither autoimmunity nor thyroid hormones are associated with PHT in these patients. Mild dyspnea during daily activities in patients with hyperthyroidism may be related to PHI; however, severe dyspnea requires further evaluation.
dc.identifier.doi10.1016/j.amjms.2017.01.016
dc.identifier.endpage380
dc.identifier.issn0002-9629
dc.identifier.issn1538-2990
dc.identifier.issue4en_US
dc.identifier.pmid28317625
dc.identifier.scopus2-s2.0-85020344844
dc.identifier.scopusqualityQ2
dc.identifier.startpage374
dc.identifier.urihttps://doi.org/10.1016/j.amjms.2017.01.016
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5689
dc.identifier.volume353
dc.identifier.wosWOS:000402163900009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorZuhur, Sayid Shafi
dc.institutionauthorKara, Sonat Pınar
dc.institutionauthorŞahin, Ertan
dc.institutionauthorElbüken, Gülşah
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofAmerican Journal of the Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHyperthyroidism
dc.subjectHypothyroidism
dc.subjectPulmonary hypertension
dc.subjectTRAb
dc.subjectAutoimmunity
dc.subjectGraves-Disease
dc.subjectArterial-Hypertension
dc.subjectCardiovascular-System
dc.subjectVascular-Resistance
dc.subjectDiagnosis
dc.subjectPressure
dc.subjectCatheterization
dc.subjectThyrotoxicosis
dc.subjectPrevalence
dc.subjectLink
dc.titleRelationship Among Pulmonary Hypertension, Autoimmunity, Thyroid Hormones and Dyspnea in Patients With Hyperthyroidism
dc.typeArticle

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