The effects of etomidate on testicular ischemia reperfusion injury in ipsilateral and contralateral testes of rats

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dc.authorscopusid57215381600
dc.authorscopusid56904163300
dc.authorscopusid57430688300
dc.authorscopusid33867696300
dc.authorscopusid7801455102
dc.contributor.authorJafarova Demirkapu, Mahluga
dc.contributor.authorKarabağ, Sevil
dc.contributor.authorAkgül, Hacı Murat
dc.contributor.authorMordeniz, Cengiz
dc.contributor.authorYananli, H.R.
dc.date.accessioned2022-05-11T14:01:33Z
dc.date.available2022-05-11T14:01:33Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstractOBJECTIVE: Testicular torsion is a condition that manifests with acute pain and can lead to infertility despite urgent surgical intervention. The aim of this study is to investigate the protective and preventive effects of etomidate, an imidazole derivative, a non-barbiturate general anesthetic agent, without analgesic effect, on testicular ischemia-reperfusion injury. MATERIALS AND METHODS: Twenty-four adult male Wistar rats weighing 200-250 g were used in the study. Torsion was created in all rats by rotating left testes 720° clockwise on the day of the experiment. 30 minutes before detorsion, 4 mg/kg etomidate and 10 mg/kg propofol were administered intraperitoneally to the etomidate and propofol groups, respectively. After an hour of ischemia, the left testis was reinstated, and the tissues were repaired according to their physiology. Following 24 hours of reperfusion, the animals were euthanized after ipsilateral and contralateral testes were removed. RESULTS: Etomidate applied before testicular detorsion significantly suppressed germ cell damage and Leydig cell loss in ipsilateral tissue. It did not cause any significant changes in the percentage of necrosis, histological score, and tubule rupture in ipsilateral tissue. Propofol administered before testicular detorsion significantly suppressed the percentage of necrosis only in the ipsilateral tissue. In addition, no signs of damage were observed in the contralateral testis. CONCLUSIONS: These findings show that etomidate administered before detortion creates a protective effect by preventing testicular ischemia- reperfusion injury. © 2022 Verduci Editore s.r.l. All rights reserved.
dc.identifier.doi10.26355/eurrev_202201_27770
dc.identifier.endpage217
dc.identifier.issn1128-3602
dc.identifier.issue1en_US
dc.identifier.pmid35048997
dc.identifier.scopus2-s2.0-85123670247
dc.identifier.scopusqualityQ2
dc.identifier.startpage211
dc.identifier.urihttps://doi.org/10.26355/eurrev_202201_27770
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4435
dc.identifier.volume26
dc.identifier.wosWOS:000745985100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorJafarova Demirkapu, Mahluga
dc.institutionauthorKarabağ, Sevil
dc.institutionauthorAkgül, Hacı Murat
dc.institutionauthorMordeniz, Cengiz
dc.language.isoen
dc.publisherVerduci Editore s.r.l
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGeneral anesthetic
dc.subjectGerm cell
dc.subjectIpsilateral and contralateral testes
dc.subjectIschemia reperfusion injury
dc.subjectLeydig cell
dc.subjectTesticular torsion and detorsion
dc.titleThe effects of etomidate on testicular ischemia reperfusion injury in ipsilateral and contralateral testes of rats
dc.typeArticle

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